• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A mechanism of resistance to 6-mercaptopurine: metabolism of hypoxanthine and 6-mercaptopurine by sensitive and resistant neoplasms.

作者信息

BROCKMAN R W

出版信息

Cancer Res. 1960 Jun;20:643-53.

PMID:13804596
Abstract
摘要

相似文献

1
A mechanism of resistance to 6-mercaptopurine: metabolism of hypoxanthine and 6-mercaptopurine by sensitive and resistant neoplasms.一种对6-巯基嘌呤的耐药机制：敏感和耐药肿瘤对次黄嘌呤及6-巯基嘌呤的代谢
Cancer Res. 1960 Jun;20:643-53.
2
Mechanism of uptake of purines by Pseudomonas aeruginosa.
Biochemistry. 1969 Feb;8(2):457-65. doi: 10.1021/bi00830a001.
3
On the biochemical modulation of 6-mercaptopurine by methotrexate in murine WEHI-3b leukemia cells in vitro.甲氨蝶呤对小鼠WEHI-3b白血病细胞中6-巯基嘌呤的体外生化调节作用
Leuk Res. 1992;16(3):275-80. doi: 10.1016/0145-2126(92)90065-f.
4
Facilitated transport of 6-mercaptopurine and 6-thioguanine and non-mediated permeation of 8-azaguanine in Novikoff rat hepatoma cells and relationship to intracellular phosphoribosylation.诺维科夫大鼠肝癌细胞中6-巯基嘌呤和6-硫鸟嘌呤的易化转运以及8-氮鸟嘌呤的非介导渗透与细胞内磷酸核糖基化的关系
Biochim Biophys Acta. 1981 Sep 21;647(1):49-62. doi: 10.1016/0005-2736(81)90294-7.
5
Formation of 6-thioxanthosine 5'-phosphate from 6-mercaptopurine and from 6-thioxanthine in Ehrlich ascites-tumour cells.
Biochim Biophys Acta. 1965 Oct 11;108(2):320-2. doi: 10.1016/0005-2787(65)90021-3.
6
Biosynthesis of the purines. I. Hypoxanthine formation in pigeon liver homogenates and extracts.
J Biol Chem. 1952 May;196(2):499-512.
7
[THE OXIDATIVE DEGRADATION OF HYPOXANTHINE AND URIC ACID BY LIVER HOMOGENATE DURING THE COURSE OF DEVELOPMENT OF THE RAT LIVER].
Acta Biol Med Ger. 1964;12:126-33.
8
Oxypurine metabolism of xanthine oxidase-deficient hepatoma-derived cell line HuH-7. Effect of exogenous purines and allopurinol.黄嘌呤氧化酶缺陷的肝癌衍生细胞系HuH-7的氧嘌呤代谢。外源性嘌呤和别嘌呤醇的作用。
Horm Metab Res. 1994 Aug;26(8):389-91. doi: 10.1055/s-2007-1001714.
9
Xanthine and hypoxanthine in amniotic fluid during pregnancy.孕期羊水中的黄嘌呤和次黄嘌呤。
Dan Med Bull. 1990 Dec;37(6):559-60.
10
Xanthine and hypoxanthine accumulation during storage may contribute to reperfusion injury following liver transplantation in the rat.
Transplant Proc. 1989 Feb;21(1 Pt 2):1319-20.

引用本文的文献

1
Molecular pharmacodynamics in childhood leukemia.儿童白血病中的分子药效学
Int J Hematol. 2003 Dec;78(5):402-13. doi: 10.1007/BF02983812.
2
[THE SIGNIFICANCE OF THE FOLIC ACID METABOLISM FOR THE NORMAL AND PATHOLOGICAL MATURATION OF BLOOD CELLS].[叶酸代谢对血细胞正常及病理成熟的意义]
Klin Wochenschr. 1963 Nov 15;41:1077-82. doi: 10.1007/BF01486507.
3
[On the mechanism of action of 6-mercaptopurine].[关于6-巯基嘌呤的作用机制]
Klin Wochenschr. 1962 Nov 15;40:1170-1. doi: 10.1007/BF01484910.
4
Human leukocyte metabolism in vitro. I. Incorporation of adenine-8-C-14 and formate-C-14 into the nucleic acids of leukemic leukocytes.人白细胞的体外代谢。I. 将腺嘌呤 -8-C¹⁴ 和甲酸 -C¹⁴ 掺入白血病白细胞的核酸中。
J Clin Invest. 1962 Jan;41(1):67-79. doi: 10.1172/JCI104468.
5
Chemotherapy of acute leukemia in childhood.儿童急性白血病的化疗
Indian J Pediatr. 1968 Dec;35(251):561-9. doi: 10.1007/BF02759680.
6
[In vitro estimation of individual tumor sensitivity to anticancer agents in order to follow surgery with specific cytotoxic therapy].[为了在手术后续以特定的细胞毒性疗法而进行的个体肿瘤对抗癌药物敏感性的体外评估]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1971;76(2):124-39. doi: 10.1007/BF00284423.
7
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].[细胞抑制剂和X射线对实体恶性肿瘤体外核酸代谢的影响]
Z Krebsforsch. 1970;74(1):76-90.
8
Molecular mechanisms of drug resistance.耐药性的分子机制
Biochem J. 1990 Dec 1;272(2):281-95. doi: 10.1042/bj2720281.
9
Parameters of acquired resistance and their role in the evaluation of new chemotherapeutic drugs.获得性耐药的参数及其在新型化疗药物评估中的作用。
Infection. 1976;4(2):61-9. doi: 10.1007/BF01638718.