抗血吸虫药物F30066在各种测试系统中的诱变作用。

Mutation induction by the antischistosomal drug F30066 in various test systems.

作者信息

Ong T M, Callen D F, Huang S L, Batzinger R P, Bueding E

出版信息

Mutat Res. 1977;48(1):37-42. doi: 10.1016/0027-5107(77)90188-9.

Abstract

The genetic activity of furapromidium (F30066), an antischistosomal drug, was studied in Salmonella typhimurium, Saccharomyces cerevisiae, Neurospora crassa and cultured Chinese hamster cells. The results show that F30066 induces gene mutations in S. typhimurium, N. crassa and Chinese hamster cells. This compound also causes gene conversions in S. cerevisiae.

摘要

对抗血吸虫药物呋喃丙胺（F30066）的遗传活性在鼠伤寒沙门氏菌、酿酒酵母、粗糙脉孢菌和培养的中国仓鼠细胞中进行了研究。结果表明，F30066在鼠伤寒沙门氏菌、粗糙脉孢菌和中国仓鼠细胞中诱导基因突变。该化合物在酿酒酵母中还会引起基因转换。