Liu Y, Kato H, Nakata N, Kogure K
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Brain Res. 1992 Jul 17;586(1):121-4. doi: 10.1016/0006-8993(92)91380-w.
We examined whether preconditioning with sublethal ischemia protects against neuronal damage following subsequent lethal ischemic insults. Forebrain ischemia for 3 min in Wistar rats increased heat shock protein-70 immunoreactivity in the hippocampal CA1 subfield but produced no neuronal damage. Preconditioning with 3 min of ischemia followed by 3 days of reperfusion protected against hippocampal CA1 neuronal damage following 6 and 8 min of ischemia but not damage after 10 min of ischemia. The result strongly suggests that stress response induced by sublethal ischemia protects against ischemic brain damage.
我们研究了亚致死性缺血预处理是否能保护神经元免受随后致死性缺血损伤的影响。在Wistar大鼠中，前脑缺血3分钟可增加海马CA1亚区热休克蛋白-70的免疫反应性，但未造成神经元损伤。3分钟缺血预处理后再灌注3天，可保护海马CA1神经元免受6分钟和8分钟缺血损伤，但不能保护10分钟缺血后的损伤。该结果强烈表明，亚致死性缺血诱导的应激反应可保护大脑免受缺血损伤。
