Gershon S, Shopsin B, Wilk S
Neuropsychobiology. 1976;2(2-3):145-60. doi: 10.1159/000117543.
This report deals with a series of experimental approaches carried out in clinical studies to attempt to examine the role of amines in relationship to affective state and the mode of action of thymoleptic agents. Attempts have been made to examine enzymes, amines and other metabolites in biological fluids to assess the role of catecholamines and indoleamines in these disorders. Synthesis inhibitors were employed in studies where antidepressant drug-induced remission was initiated and the effect of two inhibitors was assessed on the clinical state. The results are presented and discussed in regard to the significance of the role of serotonin in depressive states and the action of thymoleptic agents.
本报告涉及在临床研究中开展的一系列实验方法，旨在探讨胺类物质与情感状态的关系以及抗抑郁药的作用方式。已尝试检测生物体液中的酶、胺类及其他代谢产物，以评估儿茶酚胺和吲哚胺在这些疾病中的作用。在抗抑郁药物诱导病情缓解的研究中使用了合成抑制剂，并评估了两种抑制剂对临床状态的影响。针对血清素在抑郁状态中的作用及抗抑郁药的作用，呈现并讨论了研究结果。
