Shopsin B, Gershon S, Goldstein M, Friedman E, Wilk S
Psychopharmacol Commun. 1975;1(2):239-49.
Endogenously depressed patients who showed an antidepressant response to the tricyclic drug imipramine continued to show sustained well being after alpha-MPT was added whereas depression returned when small doses of PCPA were added for brief periods. In one patient the antidepressant response to imipramine occurred after pre- and continued treatment with alpha-MPT. Urinary excretion levels of MHPG in one of the patients studied longitudinally did not correspond to the direction of clinical affective state but did reflect anticipated changes during alpha-MPT treatment. Implications are that serotonergic mechanisms are likely involved in the anti-depressant effects of imipramine in man.
对内源性抑郁症患者而言，那些对三环类药物丙咪嗪有抗抑郁反应的患者，在加用α-甲基对酪氨酸（alpha-MPT）后持续保持良好状态，而在短期内加用小剂量对氯苯丙氨酸（PCPA）时抑郁症又复发。在一名患者中，对丙咪嗪的抗抑郁反应出现在α-甲基对酪氨酸的预处理及持续治疗之后。在纵向研究的一名患者中，3-甲氧基-4-羟基苯乙二醇（MHPG）的尿排泄水平与临床情感状态的方向不相符，但确实反映了α-甲基对酪氨酸治疗期间预期的变化。这意味着血清素能机制可能参与了丙咪嗪对人类的抗抑郁作用。
