• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

豚鼠体内组胺、5-羟色胺及乙酰胆碱拮抗剂的评估

Evaluation of antagonists of histamine, 5-hydroxytryptamine and acetylcholine in the guinea-pig.

作者信息

HOLGATE J A, WARNER B T

出版信息

Br J Pharmacol Chemother. 1960 Dec;15(4):561-6. doi: 10.1111/j.1476-5381.1960.tb00282.x.

DOI:10.1111/j.1476-5381.1960.tb00282.x
PMID:13715260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1482269/
Abstract

Changes in the resistance to entry of air into the lungs of anaesthetized guinea-pigs have been used to study the effects of histamine, 5-hydroxytryptamine, and acetylcholine. Some known antagonists of these bronchoconstrictor agents have been investigated. The degree of antagonism has been expressed in terms of the dose ratio, previously used only with in vitro preparations.

摘要

已利用麻醉豚鼠肺脏空气进入阻力的变化来研究组胺、5-羟色胺和乙酰胆碱的作用。对这些支气管收缩剂的一些已知拮抗剂进行了研究。拮抗程度已用剂量比来表示，剂量比以前仅用于体外制剂。

相似文献

1
Evaluation of antagonists of histamine, 5-hydroxytryptamine and acetylcholine in the guinea-pig.豚鼠体内组胺、5-羟色胺及乙酰胆碱拮抗剂的评估
Br J Pharmacol Chemother. 1960 Dec;15(4):561-6. doi: 10.1111/j.1476-5381.1960.tb00282.x.
2
THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM.5-羟色胺受体在豚鼠离体回肠肌间神经丛上的位点
Br J Pharmacol Chemother. 1963 Oct;21(2):306-22. doi: 10.1111/j.1476-5381.1963.tb01529.x.
3
[ON THE MECHANISM OF THE EFFECT OF BRADYKININ ON THE GUINEA PIG INTESTINE].[关于缓激肽对豚鼠肠道作用的机制]
Acta Biol Med Ger. 1964;12:443-58.
4
Analgesic antipyretic drugs as antagonists of bradykinin.作为缓激肽拮抗剂的解热镇痛药。
Br J Pharmacol Chemother. 1960 Dec;15(4):601-10. doi: 10.1111/j.1476-5381.1960.tb00288.x.
5
EFFECTS OF SMOOTH MUSCLE STIMULANTS AND THEIR ANATAGONISTS UPON POTASSIUM ION UPTAKE AND RELEASE IN STRIPS OF GUINEA-PIG ILEUM.平滑肌兴奋剂及其拮抗剂对豚鼠回肠条片中钾离子摄取和释放的影响。
J Pharm Pharmacol. 1964 Feb;16:134-6. doi: 10.1111/j.2042-7158.1964.tb07436.x.
6
THE EFFECT OF DIBENZHEPTROPINE CITRATE ON THE TONE OF THE BRONCHIAL MUSCLES.柠檬酸二苯庚托品对支气管肌肉张力的影响
Arch Int Pharmacodyn Ther. 1964 Apr 1;148:367-81.
7
The bronchoconstrictor action of bradykinin in the guinea-pig.缓激肽在豚鼠体内的支气管收缩作用。
Br J Pharmacol Chemother. 1960 Jun;15(2):290-7. doi: 10.1111/j.1476-5381.1960.tb01247.x.
8
The influence of drugs upon 42 K + fluxes in guinea-pig ileum in vitro.药物对豚鼠离体回肠42K⁺通量的影响。
Arch Int Pharmacodyn Ther. 1972;198(1):173-86.
9
[Antagonistic actions of gamma-aminobutyric acid and its derivatives against acetylcholine, 5-hydroxytryptamine, nicotine and histamine have been observed in the guinea pig ileum].在豚鼠回肠中已观察到γ-氨基丁酸及其衍生物对乙酰胆碱、5-羟色胺、尼古丁和组胺的拮抗作用。
Nihon Seirigaku Zasshi. 1961 Mar;23:161-9.
10
Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide.二乙麦角酰胺对脑中组胺激活的腺苷酸环化酶的拮抗作用。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5697-701. doi: 10.1073/pnas.74.12.5697.

引用本文的文献

1
The role of pharmacologically-active amines in resistance to Trichostrongylus colubriformis in the guinea-pig.药理活性胺在豚鼠对蛇形毛圆线虫抗性中的作用。
Immunology. 1971 Dec;21(6):925-38.
2
Humoral factors affecting pulmonary inflation during acute anaphylaxis in the guinea-pig in vivo.豚鼠体内急性过敏反应期间影响肺膨胀的体液因素。
Br J Pharmacol Chemother. 1967 Jun;30(2):283-301. doi: 10.1111/j.1476-5381.1967.tb02135.x.
3
Response of rat lung to humoral mediators of anaphylaxis and its modification by drugs and sensitization.大鼠肺对过敏反应体液介质的反应及其被药物和致敏作用的改变。
Br J Pharmacol. 1975 Nov;55(3):423-30. doi: 10.1111/j.1476-5381.1975.tb06947.x.
4
Pharmacological analysis of histamine receptors in musculature and vasculature of the dog trachea in situ.犬气管肌肉组织和血管系统中组胺受体的药理学分析（原位）
Br J Pharmacol. 1978 Dec;64(4):553-8. doi: 10.1111/j.1476-5381.1978.tb17317.x.
5
Comparative responses of tracheal spirals and parenchymal strips to histamine and carbachol in vitro.气管螺旋条和实质组织条在体外对组胺和卡巴胆碱的比较反应。
J Clin Invest. 1978 Jun;61(6):1441-7. doi: 10.1172/JCI109063.

本文引用的文献

1
Quantitative studies of antagonists for 5-hydroxytryptamine.5-羟色胺拮抗剂的定量研究。
Q J Exp Physiol Cogn Med Sci. 1955 Jan;40(1):49-74. doi: 10.1113/expphysiol.1955.sp001097.
2
The bronchoconstrictor action of bradykinin in the guinea-pig.缓激肽在豚鼠体内的支气管收缩作用。
Br J Pharmacol Chemother. 1960 Jun;15(2):290-7. doi: 10.1111/j.1476-5381.1960.tb01247.x.
3
Two kinds of tryptamine receptor.两种色胺受体。
Br J Pharmacol Chemother. 1957 Sep;12(3):323-8. doi: 10.1111/j.1476-5381.1957.tb00142.x.
4
The effects of 5-hydroxytryptamine and its antagonists on tidal air.5-羟色胺及其拮抗剂对潮气量的影响。
Br J Pharmacol Chemother. 1956 Sep;11(3):289-94. doi: 10.1111/j.1476-5381.1956.tb01068.x.
5
Superfusion as a method for the study of drug antagonism.灌注法作为研究药物拮抗作用的一种方法。
Br J Pharmacol Chemother. 1955 Sep;10(3):326-35. doi: 10.1111/j.1476-5381.1955.tb00878.x.