HICKS R, LEACH G D
Br J Pharmacol Chemother. 1963 Dec;21(3):441-9. doi: 10.1111/j.1476-5381.1963.tb02012.x.
Two methods for recording bronchoconstrictor responses to antigen injected into sensitized guinea-pigs have been used to show that the dose/response relationship is a normal pharmacological one characterized by a sigmoid curve. Studies of desensitization indicate that the progressive decrease in sensitivity to repeated administrations of the same dose of antigen follows an exponential pattern. It is suggested that this approach might form a basis for reliable quantitative investigations of anaphylactic phenomena.
已采用两种方法记录致敏豚鼠注射抗原后的支气管收缩反应，结果表明剂量/反应关系是一种典型的药理学关系，呈S形曲线。脱敏研究表明，对同一剂量抗原重复给药时敏感性的逐渐降低呈指数模式。有人认为，这种方法可能为过敏现象的可靠定量研究奠定基础。
