CD7在恶性胸膜间皮瘤中的表达。
CD7 expression in malignant pleural mesothelioma.
作者信息
Hibi S, Kataoka Y, Fujita N, Okabe H, Yoshikawa K, Seto M, Ueda R, Imashuku S
机构信息
Division of Pediatrics, Children's Research Hospital, Kyoto.
出版信息
Jpn J Cancer Res. 1992 Jul;83(7):680-3. doi: 10.1111/j.1349-7006.1992.tb01965.x.
CD7 antigen was found to be expressed on malignant mesothelioma arising from the right pleura in a 15-year-old girl not only by immunostaining using monoclonal antibodies, but also by Northern blot analysis. The level of expression in this tumor was comparable to those in T-cell lines, Jurkat and CCRF-CEM. Cytogenetic analysis of the tumor showed hypodiploidy (n = 43). CD7 has been regarded as one of the hematopoietic cell markers selectively expressed on the majority of T cells and multipotential stem cells. To our knowledge, this is the first report of a non-hematopoietic tumor expressing CD7.
在一名15岁女孩中，发现起源于右胸膜的恶性间皮瘤不仅通过使用单克隆抗体的免疫染色，而且通过Northern印迹分析表达CD7抗原。该肿瘤中的表达水平与T细胞系Jurkat和CCRF-CEM中的表达水平相当。对该肿瘤的细胞遗传学分析显示亚二倍体（n = 43）。CD7被认为是在大多数T细胞和多能干细胞上选择性表达的造血细胞标志物之一。据我们所知，这是关于非造血肿瘤表达CD7的首次报道。
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