Takeyama K, Tobinai K, Shimoyama M
Nihon Rinsho. 1992 Jun;50(6):1414-8.
High dose chemotherapy (HDCT) followed by autologous bone marrow transplantation (ABMT) is one of the cure-oriented therapies for hematologic malignancies. Colony stimulating factors (CSFs) are currently used to stimulate hematopoiesis in various cytopenic conditions including post BMT. Granulocyte CSF (G-CSF) significantly accelerates granulocyte recovery after ABMT. Earlier recovery of neutrophils is associated with lower incidence of severe infections and shorter duration of reverse barrier nursing and hospitalization. Widespread use of G-CSF in ABMT may contribute to managing this treatment safely in multi-centers. Further prospective clinical study to define the optimal application and timing of HDCT with ABMT in hematologic malignancies is required.
大剂量化疗（HDCT）后进行自体骨髓移植（ABMT）是血液系统恶性肿瘤的一种以治愈为导向的治疗方法。集落刺激因子（CSF）目前用于在包括骨髓移植后在内的各种血细胞减少症中刺激造血。粒细胞集落刺激因子（G-CSF）可显著加速自体骨髓移植后粒细胞的恢复。中性粒细胞的早期恢复与严重感染发生率较低、反向隔离护理和住院时间较短有关。G-CSF在自体骨髓移植中的广泛应用可能有助于在多中心安全地管理这种治疗。需要进一步进行前瞻性临床研究，以确定血液系统恶性肿瘤中HDCT联合ABMT的最佳应用和时机。
