DHAWAN B N, SAXENA P N
Br J Pharmacol Chemother. 1960 Jun;15(2):285-9. doi: 10.1111/j.1476-5381.1960.tb01246.x.
Apomorphine produced persistent pecking in pigeons, the latent period, intensity and duration of which were related to the dose. The ED50 was estimated as 78.1+/-11.1 mug./kg. On chronic administration of apomorphine there was a significant decrease in latent period and weight which quickly returned to normal on stopping the drug. No conditioning and no tolerance were observed. The uncertain emetic effect of apomorphine in pigeons has been confirmed. Ten other centrally acting agents tested (caffeine, cocaine, 5-hydroxytryptamine, lysergic acid diethylamide, methamphetamine, morphine, nalorphine, pentylenetetrazol, strychnine, and yohimbine) failed to produce similar effects in pigeons.
阿扑吗啡可使鸽子产生持续啄食行为，其潜伏期、强度和持续时间与剂量有关。估计其半数有效剂量（ED50）为78.1±11.1微克/千克。长期给予阿扑吗啡后，潜伏期和体重显著下降，停药后迅速恢复正常。未观察到条件反射和耐受性。阿扑吗啡对鸽子的催吐作用不确切已得到证实。所测试的其他十种中枢作用药物（咖啡因、可卡因、5-羟色胺、麦角酸二乙胺、甲基苯丙胺、吗啡、烯丙吗啡、戊四氮、士的宁和育亨宾）在鸽子身上未产生类似作用。
