Pekonen F, Rutanen E M, Kurunmäki H, Hovatta O
Minerva Institute for Medical Research, Helsinki, Finland.
Int J Fertil. 1992 May-Jun;37(3):188-91.
The effect of ovulation induction on serum insulin-like growth factor binding protein 1 (IGFBP-1) level in relation to sex hormone binding globulin (SHBG) levels was evaluated. Serum samples were collected 8 to 12 days after ovulation from 26 women undergoing ovulation induction with clomiphene citrate (CC), and from 58 women treated with CC in combination with human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG). In addition, serum samples were obtained from 63 spontaneously ovulating women and from 12 women during an anovulatory cycle. Luteal phase serum IGFBP-1 levels were 4.22 +/- 2.95 micrograms/L (P less than .05) in the CC group and 7.31 +/- 6.13 micrograms/L (P less than .001) in the CC/hMG/hCG group as compared to unstimulated ovulatory cycles (2.64 +/- 2.52 micrograms/L). No significant difference in IGFBP-1 levels was seen between spontaneously ovulatory and anovulatory cycles. The serum IGFBP-1 levels correlated positively to SHBG levels (r = .52, P less than .001). The data show that ovulation induction increases serum IGFBP-1 levels in parallel to SHBG levels, indicating that ovarian stimulation, which results in increased steroid hormone production, also induces changes in other factors known to modulate steroid hormone actions.
评估了促排卵对血清胰岛素样生长因子结合蛋白1（IGFBP-1）水平与性激素结合球蛋白（SHBG）水平关系的影响。在排卵后8至12天，收集了26名接受枸橼酸氯米芬（CC）促排卵的女性、58名接受CC联合人绝经期促性腺激素（hMG）和人绒毛膜促性腺激素（hCG）治疗的女性的血清样本。此外，还从63名自然排卵的女性和12名无排卵周期的女性中获取了血清样本。与未刺激的排卵周期（2.64±2.52微克/升）相比，CC组黄体期血清IGFBP-1水平为4.22±2.95微克/升（P＜0.05），CC/hMG/hCG组为7.31±6.13微克/升（P＜0.001）。自然排卵周期和无排卵周期之间的IGFBP-1水平无显著差异。血清IGFBP-1水平与SHBG水平呈正相关（r = 0.52，P＜0.001）。数据表明，促排卵会使血清IGFBP-1水平与SHBG水平平行升高，这表明导致类固醇激素产生增加的卵巢刺激也会诱导其他已知调节类固醇激素作用的因素发生变化。
