Breznik R, Adamcic M, Borko E, Vlaisavljević V
Jugosl Ginekol Opstet. 1984 Sep-Dec;24(5-6):84-6.
Ovulation was stimulated in 56 cycles, namely in 16 cycles with clomiphene, in 19 with clomiphene and HCG, and in 16 cycles with clomiphene, HMG and HCG. In three women there was no LH or estradiol increase following ovulation stimulation with clomiphene, but in two women stimulated by the two remaining methods there was a spontaneous LH peak before the application of HCG. Using the radioimmunologic method once a day the concentrations of LH, estradiol and SHBG in serum were determined. The concentrations of SHBG in serum do not change in all three methods of ovulation stimulation. The mean concentrations of SHBG vary between 47 and 54 mumol/l during the entire preovulatory phase of the stimulated cycle. All of these cycles were ovulatory since the preovulatory E2 peak is clearly expressed in all three methods of ovulation stimulation.
对56个周期进行了促排卵，即16个周期使用克罗米芬，19个周期使用克罗米芬和人绒毛膜促性腺激素（HCG），16个周期使用克罗米芬、人绝经期促性腺激素（HMG）和HCG。有三名女性在使用克罗米芬促排卵后促黄体生成素（LH）或雌二醇未升高，但在另外两种促排卵方法刺激的两名女性中，在应用HCG之前出现了自发的LH峰值。每天使用放射免疫法测定血清中LH、雌二醇和性激素结合球蛋白（SHBG）的浓度。在所有三种促排卵方法中，血清中SHBG的浓度均无变化。在受刺激周期的整个排卵前期，SHBG的平均浓度在47至54μmol/L之间变化。所有这些周期均为排卵周期，因为在所有三种促排卵方法中，排卵前雌二醇（E2）峰值均明显出现。
