Gulati S, Marwaha R K, Prakash D, Ayyagari A, Singhi S, Kumar L, Singhi P, Walia B N
Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ann Trop Paediatr. 1992;12(2):137-41. doi: 10.1080/02724936.1992.11747558.
Enteric fever caused by Salmonella typhi resistant to all the standard first-line antibiotics is emerging as a major problem in developing countries. Fifteen such culture-proven cases were treated with ceftriaxone (6), cefotaxime (5) or ciprofloxacin (4). The earliest defervescence occurred with ceftriaxone (mean 3.3 days). Clinical cures were obtained with all three drugs with only one child having a relapse. Ciprofloxacin, by virtue of its cost and an oral route of administration, is the ideal choice in a developing country.
由对所有标准一线抗生素耐药的伤寒沙门氏菌引起的肠热症，正在发展中国家成为一个主要问题。15例经培养证实的此类病例接受了头孢曲松（6例）、头孢噻肟（5例）或环丙沙星（4例）治疗。最早退热的是使用头孢曲松的患者（平均3.3天）。三种药物均取得了临床治愈效果，只有一名儿童复发。鉴于其成本和口服给药途径，环丙沙星是发展中国家的理想选择。
