血清γ-球蛋白浓度与疟疾和镰状化的关系。
The relationship of serum gamma-globulin concentration to malaria and sickling.
作者信息
EDOZIEN J C, BOYO A E, MORLEY D C
出版信息
J Clin Pathol. 1960 Mar;13(2):118-23. doi: 10.1136/jcp.13.2.118.
Abstract
The serum protein patterns of groups of Nigerians including 98 children partially protected by "daraprim" against malaria, and 113 unprotected children, have been studied. The protected children have a significantly lower concentration of serum gamma globulin than the unprotected children from the age of 12 months onwards. In children, sicklers have a significantly higher serum gamma globulin than non-sicklers. It is suggested that sickling protects against malaria by enhancing the antibody response against the malaria parasite.
摘要
对包括98名部分受“达拉匹林”保护免受疟疾侵害的儿童以及113名未受保护儿童在内的尼日利亚人群的血清蛋白模式进行了研究。从12个月起，受保护儿童的血清γ球蛋白浓度明显低于未受保护儿童。在儿童中，镰状细胞贫血患者的血清γ球蛋白明显高于非镰状细胞贫血患者。有人提出，镰状细胞状态通过增强针对疟原虫的抗体反应来预防疟疾。
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