利尿剂对鼻黏膜跨膜电位差的影响。

The effects of diuretics on nasal transmucosal potential difference.

作者信息

Stewart E J, Cinnamond M J, Nicholls P, Stanford C F

机构信息

Eye and Ear Clinic, Royal Victoria Hospital, Belfast, Northern Ireland.

出版信息

Clin Otolaryngol Allied Sci. 1992 Aug;17(4):351-3. doi: 10.1111/j.1365-2273.1992.tb01011.x.

DOI:10.1111/j.1365-2273.1992.tb01011.x

PMID:1382003

Abstract

The effects of application of frusemide, amiloride and bumetanide on nasal transmucosal potential difference (NTPD), at rest and during exercise, were studied in 8 normal subjects. In a double-blind placebo controlled study, 8 volunteers had NTPD recorded at 4-min intervals during 12-min periods of rest, before and after treatment, during 12 min of exercise, and recovery. Application of placebo, frusemide and bumetanide did not significantly alter NTPD at rest. Amiloride caused a significant reduction (P less than 0.025). During exercise there was a significant rise in NTPD with placebo (P less than 0.05), frusemide (P less than 0.05) and amiloride (P less than 0.05). There was no increase in NTPD during exercise with bumetanide.

摘要

在8名正常受试者中，研究了速尿、氨氯吡咪和布美他尼在静息及运动状态下对鼻黏膜电位差（NTPD）的影响。在一项双盲安慰剂对照研究中，8名志愿者在治疗前后的12分钟静息期、12分钟运动期及恢复过程中，每隔4分钟记录一次NTPD。应用安慰剂、速尿和布美他尼对静息时的NTPD无显著影响。氨氯吡咪使NTPD显著降低（P<0.025）。运动期间，安慰剂（P<0.05）、速尿（P<0.05）和氨氯吡咪（P<0.05）使NTPD显著升高。使用布美他尼时，运动期间NTPD未升高。