吡咯他尼、布美他尼和呋塞米对正常受试者电解质及尿酸盐排泄的影响。
Effects of piretanide, bumetanide and frusemide on electrolyte and urate excretion in normal subjects.
作者信息
Roberts C J, Homeida M, Roberts F, Bogie W
出版信息
Br J Clin Pharmacol. 1978 Aug;6(2):129-33. doi: 10.1111/j.1365-2125.1978.tb00837.x.
Abstract
- The pharmacological actions of a new short acting loop diuretic were investigated in nine healthy male subjects and compared with those of frusemide and bumetanide. Subjects received 6 mg piretanide/day, 40 mg frusemide/day or 1 mg bumetanide/day for a period of 1 week. 2. Comparison of effects following the first dose administered showed that 6 mg piretanide is of similar potency to 40 mg frusemide in terms of diuresis, natriuresis and kaliuresis but is less potent than 1 mg bumetanide. 3. All three diuretics caused a decrease in urate excretion and a rise in serum uric acid. 4. Piretanide was well tolerated. Further investigation is required to ascertain what clinical advantage it offers over frusemide and bumetanide.
摘要
- 在9名健康男性受试者中研究了一种新型短效袢利尿剂的药理作用，并与呋塞米和布美他尼进行了比较。受试者连续1周每天服用6毫克吡咯他尼、40毫克呋塞米或1毫克布美他尼。2. 首次给药后效果的比较表明，就利尿、利钠和利钾作用而言，6毫克吡咯他尼与40毫克呋塞米效力相似，但不如1毫克布美他尼效力强。3. 这三种利尿剂均导致尿酸排泄减少和血清尿酸升高。4. 吡咯他尼耐受性良好。需要进一步研究以确定它相对于呋塞米和布美他尼具有哪些临床优势。
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