Biava P M, Audisio R, Centonze A, Barbieri A, Bisanti L, Duca G
Unità Operativa Ospedaliera di Medicina del Lavoro, U.S.S.L. 65, Sesto S. Giovanni, MI.
Med Lav. 1992 May-Jun;83(3):249-58.
An investigation on the health effects of occupational exposure to motor vehicle exhaust and environmental pollutants was carried out on traffic wardens in Milan (Italy). Randomized samples of 292 traffic wardens (exposed group) and 60 hospital staff members (control group) underwent a physical examination and laboratory tests. No significant difference was observed between the exposed and control groups as regards general morbidity, apart from musculo-skeletal disorders in females. The mean blood lead level (PbB) among traffic wardens was 15.2 micrograms/dl compared with 11.7 in control (p less than 0.01). The carboxyhaemoglobin concentration (COHb) in traffic wardens at the beginning of the shift was 2.8% for smokers and 1.2% for non-smokers (3.0% and 0.9% respectively in controls). At the end of the shift COHb in the exposed group was 4.3% for smokers and 2.5% for non-smokers (p less than 0.01). PbB was significantly correlated (r = 0.17) with Median Nerve Motor Conduction Velocity (NCV) in the exposed but not in the control group. The same pattern was observed for the correlation of PbB and Systolic Blood Pressure (SBP) (r = -0.24). COHb was significantly correlated with HDL cholesterol (r = -0.20) in the exposed group only. It is questionable whether very low PbB levels can affect NCV and SBP directly or rather whether PbB, as well as COHb, should be regarded as tracers of exposure to those urban pollutants leading also to cardiovascular and nervous disorders.
针对意大利米兰交通协管员职业暴露于机动车尾气和环境污染物对健康的影响展开了一项调查。随机抽取了292名交通协管员(暴露组)和60名医院工作人员(对照组)进行体格检查和实验室检测。除女性肌肉骨骼疾病外,暴露组和对照组在一般发病率方面未观察到显著差异。交通协管员的平均血铅水平(PbB)为15.2微克/分升,而对照组为11.7微克/分升(p<0.01)。轮班开始时,交通协管员中吸烟者的碳氧血红蛋白浓度(COHb)为2.8%,非吸烟者为1.2%(对照组吸烟者和非吸烟者分别为3.0%和0.9%)。轮班结束时,暴露组中吸烟者的COHb为4.3%,非吸烟者为2.5%(p<0.01)。在暴露组中,PbB与正中神经运动传导速度(NCV)显著相关(r=0.17),而对照组未观察到这种相关性。PbB与收缩压(SBP)的相关性也呈现相同模式(r=-0.24)。仅在暴露组中,COHb与高密度脂蛋白胆固醇(HDL胆固醇)显著相关(r=-0.20)。极低的PbB水平是否能直接影响NCV和SBP,或者说PbB以及COHb是否应被视为接触那些也会导致心血管和神经疾病的城市污染物的标志物,这是值得怀疑的。