Bono R, Piccioni P, Traversi D, Degan R, Grosa M, Bosello G, Gilli G, Arossa W, Bugiani M
Department of Public Health and Microbiology, University of Torino, via Santena 5 bis, 10126 Torino, Italy.
Sci Total Environ. 2007 Apr 15;376(1-3):109-15. doi: 10.1016/j.scitotenv.2007.01.086. Epub 2007 Feb 26.
Toxicological potential of carbon monoxide (CO) on humans is well known. Nevertheless, CO is still considered as a useful marker to detect some environmental and occupational human risk factors typical of cities. The role played by traffic pollution, indoor air quality in offices and tobacco smoke on the expression of carboxyhemoglobin (COHb%) levels was investigated in a large group of traffic policemen in Torino city (North-Western Italy). At the end of the working shift, 228 policemen responded to a questionnaire, weight and height recorded, urine spot samples collected to measure cotinine as biomarker of tobacco smoke exposure, and an arterial blood sample was taken to measure COHb levels. Data of outdoor urban air-CO were collected and to each subject a "CO outdoor air measurement" was related to his/her COHb level. Considering the annual trend of air-CO pollution from 2002 to 2004, one can assume that a general improvement of air quality in Torino was evident. Taking into account the environments where policemen work (urban outdoor and indoor), and analyzing their COHb% content, the traffic-congested areas, and, in general, the outdoor urban environment were equally risky as offices. Furthermore, if compared to CO arising from traffic-congested areas or other outdoor environments, the traffic policemen in Torino city demonstrate COHb% levels largely due to smoking habits.
一氧化碳（CO）对人体的毒理学影响是众所周知的。然而，CO仍被视为检测城市中一些典型环境和职业人类风险因素的有用标志物。在意大利西北部都灵市的一大群交通警察中，研究了交通污染、办公室室内空气质量和烟草烟雾对碳氧血红蛋白（COHb%）水平表达的影响。在工作班次结束时，228名警察回答了一份问卷，记录了体重和身高，采集了尿斑样本以测量可替宁作为烟草烟雾暴露的生物标志物，并采集了动脉血样本以测量COHb水平。收集了城市室外空气中CO的数据，并将每个受试者的“室外空气CO测量值”与其COHb水平相关联。考虑到2002年至2004年空气CO污染的年度趋势，可以假设都灵的空气质量有了明显的总体改善。考虑到警察工作的环境（城市室外和室内），并分析他们的COHb%含量，交通拥堵地区以及一般来说城市室外环境与办公室同样危险。此外，与交通拥堵地区或其他室外环境产生的CO相比，都灵市的交通警察的COHb%水平很大程度上归因于吸烟习惯。
