Salieva R M, Yanovskii K, Ratsak R, Oeme P, Sudakov K V, Yumatov E A
P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
Neurosci Behav Physiol. 1992 Jul-Aug;22(4):275-9. doi: 10.1007/BF01182865.
The influence of delta sleep-inducing peptide (DSIP, 60 and 120 nmole/kg, intraperitoneally) on the content of substance P (SP) in the hypothalamus of rats was studied in male rats of the August line. It was demonstrated that the administration of DSIP significantly increases the average content of SP in the hypothalamus, as well as its content in animals resistant to and predisposed to emotional stress. A daily one-time administration of DSIP before placing the rats in conditions of stress increases the content of SP in the hypothalamus which was decreased during emotional stress. The preliminary one-time administration of DSIP to animals subjected to a stressor influence also increases the SP content in the hypothalamus. It was established that a one-time administration of DSIP in a dose of 60 nmole/kg sharply decreases the classical manifestations of stress such as the hypertrophy of the adrenals and involution of the thymus.
在八月品系的雄性大鼠中，研究了δ睡眠诱导肽（DSIP，60和120纳摩尔/千克，腹腔注射）对大鼠下丘脑P物质（SP）含量的影响。结果表明，给予DSIP可显著增加下丘脑SP的平均含量，以及其在抗情绪应激和易患情绪应激动物中的含量。在将大鼠置于应激条件之前每日一次性给予DSIP，可增加下丘脑SP的含量，而该含量在情绪应激期间会降低。对受到应激源影响的动物预先一次性给予DSIP，也会增加下丘脑的SP含量。已确定，一次性给予60纳摩尔/千克剂量的DSIP可显著降低应激的经典表现，如肾上腺肥大和胸腺退化。
