Albrecht J C, Nicholas J, Cameron K R, Newman C, Fleckenstein B, Honess R W
Institut für Klinische und Molekulare Virologie, Friedrich-Alexander Universität Erlangen-Nürnberg, Germany.
Virology. 1992 Sep;190(1):527-30. doi: 10.1016/0042-6822(92)91247-r.
Herpesvirus saimiri (HSV) is a T-lymphotropic tumor virus that causes fulminant lymphomas and leukemias in various New World primates other than its natural host, the squirrel monkey (Saimiri sciureus). In the course of completing the nucleotide sequence of its genome, we identified an open reading frame of 363 nucleotides, designated HVS-15, that has no detectable homology to any other viral sequences to date. HVS-15 encodes a 121-amino-acid protein which shows significant similarities to human CD59, a phosphatidyl-inositol-glycan-anchored glycoprotein involved in T-cell activation and restriction of complement-mediated lysis. The predicted HVS-15 gene product is more similar to human CD59 than to the related murine Ly-6 antigens. A nucleotide sequence identity of 64% was found between HVS-15 and the CD59 reading frame, and a 48% identity exists between the corresponding protein sequences. The comparison of the amino acid sequences revealed a number of conserved structural features such as a similar pattern of hydrophobic termini and an identical cysteine skeleton.
赛米利疱疹病毒（HSV）是一种嗜T淋巴细胞肿瘤病毒，在除其天然宿主松鼠猴（Saimiri sciureus）之外的各种新大陆灵长类动物中可引发暴发性淋巴瘤和白血病。在完成其基因组核苷酸序列测定的过程中，我们鉴定出一个363个核苷酸的开放阅读框，命名为HVS - 15，迄今为止，它与任何其他病毒序列均无可检测到的同源性。HVS - 15编码一种121个氨基酸的蛋白质，该蛋白质与人类CD59具有显著相似性，CD59是一种参与T细胞活化和补体介导的细胞溶解限制的磷脂酰肌醇聚糖锚定糖蛋白。预测的HVS - 15基因产物与人类CD59的相似性高于与相关的小鼠Ly - 6抗原的相似性。在HVS - 15与CD59阅读框之间发现核苷酸序列同一性为64%，在相应蛋白质序列之间存在48%的同一性。氨基酸序列比较揭示了许多保守的结构特征，如相似的疏水末端模式和相同的半胱氨酸骨架。
