Kizaki M, Nakajima H, Ikeda Y
Division of Hematology, Keio University School of Medicine, Tokyo, Japan.
Hum Cell. 1992 Jun;5(2):103-9.
Human myeloid leukemia cells do not differentiate into functional end-cells but remain in the proliferation pool. Human cell lines can serve as model for hematopoietic cells arrested at different stages of myeloid differentiation and helps to dissect the cellular and molecular events involved in leukemogenesis. Furthermore, several agents have been identified as inducers of differentiation of leukemia cells. Exciting new clinical observation have shown that patients with APL respond well to the treatment with all-trans retinoic acid. RAR-alpha gene was proved to translocated from chromosome 17 to a locus PML on chromosome 15. This new chimeric gene, PML-RAR alpha is extremely important to understand the leukemogenesis of APL.
人类髓系白血病细胞不会分化为功能性终末细胞，而是停留在增殖池中。人类细胞系可作为处于髓系分化不同阶段的造血细胞的模型，有助于剖析白血病发生过程中涉及的细胞和分子事件。此外，已鉴定出几种可诱导白血病细胞分化的因子。令人兴奋的新临床观察结果表明，急性早幼粒细胞白血病（APL）患者对全反式维甲酸治疗反应良好。已证实维甲酸受体α（RAR-α）基因从17号染色体易位至15号染色体上的早幼粒细胞白血病（PML）基因座。这种新的嵌合基因，即早幼粒细胞白血病维甲酸受体α（PML-RARα），对于理解急性早幼粒细胞白血病的白血病发生极为重要。
