绵羊和犬激肽释放酶-激肽系统的比较。
A comparison of the kallikrein-kinin system in sheep and dogs.
作者信息
GADDUM J H, GUTH P S
出版信息
Br J Pharmacol Chemother. 1960 Mar;15(1):181-4. doi: 10.1111/j.1476-5381.1960.tb01229.x.
Three preparations of kallikrein, made from the urine of man, dog and sheep, all formed active kinins when incubated with the plasma of sheep or dogs. The six kinins could not be distinguished from one another by parallel assays on guinea-pig ileum, rat uterus and rat duodenum; they are thought to be identical, or nearly so. As judged by the amount of kinin produced, a sample of dog plasma appeared to contain about 4.3 times as much substrate as a sample of sheep plasma. This ratio did not depend on the kallikrein used. Attempts to compare the three kallikreins gave inconsistent results which may be due to presence in the preparations of kallikrein of other enzymes acting on the same substrate. Sheep plasma does not form kinins on contact with glass.
由人、狗和羊的尿液制备的三种激肽释放酶，在与绵羊或狗的血浆一起孵育时，均能形成活性激肽。通过对豚鼠回肠、大鼠子宫和大鼠十二指肠进行平行测定，无法区分这六种激肽；它们被认为是相同的，或者几乎相同。从产生的激肽量判断，一份狗血浆样本所含的底物似乎是一份绵羊血浆样本的约4.3倍。该比例不取决于所使用的激肽释放酶。比较这三种激肽释放酶的尝试得到了不一致的结果，这可能是由于激肽释放酶制剂中存在作用于同一底物的其他酶。绵羊血浆与玻璃接触时不会形成激肽。
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