[The role of the kallikrein-kinin system in the pathogenesis of leptospirosis].

The author studied the clinical and biochemical characteristic of leptospirosis in 101 patients and the changes of the components of the kallikrein-kinin system during the dynamics of the disease and the valuation of its prognosticated importance. In 26 patients she determined the level of prekallikrein and kallikrein in serum. Furthermore author measured level of components of kallikrein-kinin system in 16 guinea-pigs, infected with different virulence L. icterohaemorrhagie. She determined the serum prekallikrein and kallikrein in 20 control persons and 10 healthy guinea-pigs. At the peak of the disease the decreased level of prekallikrein with increased kallikrein activity at the same time was evaluated as in one respect its reduced synthesis in the liver, on the other hand by change of proenzyme into active form. In the phase of reconvalescence the normalization of the level of prekallikrein was missing. In these patients who got over the illness of icteric leptospirosis with acute renal failure at the controlled examination increased prekallikrein were found that supposed the absence of normalization of metabolism of kinins. On the basis of these data and experimental results author can establish that the components of kallikrein-kinin system in the high degree reflect the functional condition of liver and kidney at different phase of the disease.