Kecskés B
Pavlov Orvostudományi Egyetem, Szentpétervár, Fertözö Betegségek Tanszéke.
Orv Hetil. 1994 Aug 28;135(35):1913-7.
The author studied the clinical and biochemical characteristic of leptospirosis in 101 patients and the changes of the components of the kallikrein-kinin system during the dynamics of the disease and the valuation of its prognosticated importance. In 26 patients she determined the level of prekallikrein and kallikrein in serum. Furthermore author measured level of components of kallikrein-kinin system in 16 guinea-pigs, infected with different virulence L. icterohaemorrhagie. She determined the serum prekallikrein and kallikrein in 20 control persons and 10 healthy guinea-pigs. At the peak of the disease the decreased level of prekallikrein with increased kallikrein activity at the same time was evaluated as in one respect its reduced synthesis in the liver, on the other hand by change of proenzyme into active form. In the phase of reconvalescence the normalization of the level of prekallikrein was missing. In these patients who got over the illness of icteric leptospirosis with acute renal failure at the controlled examination increased prekallikrein were found that supposed the absence of normalization of metabolism of kinins. On the basis of these data and experimental results author can establish that the components of kallikrein-kinin system in the high degree reflect the functional condition of liver and kidney at different phase of the disease.
作者研究了101例钩端螺旋体病患者的临床和生化特征，以及激肽释放酶-激肽系统各成分在疾病动态过程中的变化及其预后重要性的评估。她测定了26例患者血清中前激肽释放酶和激肽释放酶的水平。此外，作者还测定了16只感染不同毒力出血性黄疸钩端螺旋体的豚鼠体内激肽释放酶-激肽系统各成分的水平。她还测定了20名对照人员和10只健康豚鼠的血清前激肽释放酶和激肽释放酶。在疾病高峰期，前激肽释放酶水平降低，同时激肽释放酶活性增加，一方面被认为是肝脏中其合成减少，另一方面是由于酶原转变为活性形式。在恢复期，前激肽释放酶水平未恢复正常。在这些患有黄疸型钩端螺旋体病并伴有急性肾衰竭且已康复的患者的对照检查中，发现前激肽释放酶增加，这表明激肽代谢未恢复正常。基于这些数据和实验结果，作者可以确定激肽释放酶-激肽系统的成分在很大程度上反映了疾病不同阶段肝脏和肾脏的功能状态。
