Trott K R, Bölükbasi E
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Dec 9;87(3):301-9. doi: 10.1007/BF00506503.
The dependence of the surviving fraction of Chinese hamster cells in vitro upon the concentration of Thio-TEPA, upon the duration of drug exposure and upon fractionation of drug exposure has been studied. Given a constant exposure time, the surviving fraction decreased according to a "shoulder" curve with increasing concentration. Given a constant concentration, the surviving fraction decreased exponentially with increasing exposure time. Splitting exposure of 60 min into two 30 minutes' exposures with drug-free intervals of several hours increased the cytostatic effect of Thio-TEPA.
