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Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-L-norleucine.

作者信息

GRAYZEL A I, SEEGMILLER J E, LOVE E

出版信息

J Clin Invest. 1960 Mar;39(3):447-54. doi: 10.1172/JCI104057.

DOI:10.1172/JCI104057
PMID:13829149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC293323/
Abstract
摘要

相似文献

1
Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-L-norleucine.使用6-重氮-5-氧代-L-正亮氨酸对痛风患者尿酸合成的抑制作用。
J Clin Invest. 1960 Mar;39(3):447-54. doi: 10.1172/JCI104057.
2
Inhibition of uric acid biosynthesis in birds by o-diazoacetyl-L-serine (azaserine) and 6-diazo-5-oxo-L-norleucine (DON).邻重氮乙酰基-L-丝氨酸（偶氮丝氨酸）和6-重氮-5-氧代-L-正亮氨酸（DON）对鸟类尿酸生物合成的抑制作用。
Am J Physiol. 1958 Oct;195(1):244-50. doi: 10.1152/ajplegacy.1958.195.1.244.
3
The effect of azaserine and 6-diazo-5-oxo-L-norleucine on the biosynthesis of inosinic acid de novo.重氮丝氨酸和6-重氮-5-氧代-L-正亮氨酸对肌苷酸从头生物合成的影响。
Tex Rep Biol Med. 1957;15(1):148-53.
4
Effects of 6-diazo-5-oxo-L-norleucine on the incorporation of precursors into nucleic acids.6-重氮-5-氧代-L-正亮氨酸对前体掺入核酸的影响。
Cancer Res. 1962 Aug;22:908-14.
5
Alterations in calcium metabolism in cancer patients treated with 6-diazo-5-oxo-L-norleucine.
Proc Soc Exp Biol Med. 1956 Nov;93(2):314-8. doi: 10.3181/00379727-93-22741.
6
A comparative study of 6-diazo-5-oxo-L-norleucine and O-diazoacety-L-serine on sarcoma 180.6-重氮-5-氧代-L-正亮氨酸和O-重氮乙酰基-L-丝氨酸对肉瘤180的比较研究。
Antibiot Chemother (Northfield). 1957 Dec;7(12):653-71.
7
Biosynthesis of the purines. XV. The effect of aza-L-serine and 6-diazo-5-oxo-L-norleucine on inosinic acid biosynthesis de novo.嘌呤的生物合成。十五。氮杂-L-丝氨酸和6-重氮-5-氧代-L-正亮氨酸对从头合成肌苷酸的影响。
J Biol Chem. 1957 Mar;225(1):163-76.
8
6-Diazo-5-oxo-L-norleucine, a new tumor-inhibitory substance. I. Biologic studies.
Antibiot Chemother (Northfield). 1956 Aug;6(8):487-97.
9
Effect of 6 diazo 5 oxo l-norleucine on the rat litter in utero.
Proc Soc Exp Biol Med. 1957 Jan;94(1):33-5. doi: 10.3181/00379727-94-22848.
10
6-Diazo-5-oxo-L-norleucine, a new tumor-inhibitory substance. V. Microbiologic studies of mode of action.6-重氮-5-氧代-L-正亮氨酸，一种新型肿瘤抑制物质。V. 作用模式的微生物学研究
Antibiot Chemother (Northfield). 1957 Feb;7(2):81-9.

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We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of .我们尚未达成“DON”：. 的最佳剂量和前药传递
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The effects of azathioprine (imuran) on purine synthesis in clinical disorders of purine metabolism.巯嘌呤（依木兰）对嘌呤代谢临床紊乱中嘌呤合成的影响。
J Clin Invest. 1967 Sep;46(9):1518-29. doi: 10.1172/JCI105643.
7
Uric acid production in gout.痛风中的尿酸生成
J Clin Invest. 1961 Jul;40(7):1304-14. doi: 10.1172/JCI104360.
8
The treatment of gout and disorders of uric acid metabolism with allopurinol.用别嘌醇治疗痛风及尿酸代谢紊乱
Can Med Assoc J. 1966 Nov 26;95(22):1120-7.
9
Hyperuricaemia: some biochemical aspects.高尿酸血症：一些生化方面
Proc R Soc Med. 1969 Aug;62(8):853-7. doi: 10.1177/003591576906200846.
10
Current concepts of hyperuricemia and gout.高尿酸血症与痛风的当前概念。
Calif Med. 1969 Mar;110(3):231-44.

本文引用的文献

1
The metabolism of uric acid in the normal and gouty human studied with the aid of isotopic uric acid.借助同位素尿酸对正常人和痛风患者体内尿酸的代谢进行研究。
J Biol Chem. 1949 Nov;181(1):183-93.
2
Incorporation of glycine nitrogen into uric acid in normal and gouty man.正常人和痛风患者体内甘氨酸氮掺入尿酸的情况。
Metabolism. 1952 Jan;1(1):3-12.
3
The enzymatic spectrophotometric method for determination of uric acid.用于测定尿酸的酶促分光光度法。
J Lab Clin Med. 1959 Dec;54:903-13.
4
Excessive uric acid production in the human induced by 2-ethylamino-1,3,4-thiadiazole.2-乙氨基-1,3,4-噻二唑诱导人体产生过量尿酸。
Nature. 1959 May 23;183(4673):1463-4. doi: 10.1038/1831463a0.
5
Studies of the uricogenic effect of 2-substituted thiadiazoles in man.2-取代噻二唑对人体尿酸生成作用的研究。
J Clin Invest. 1959 Jun;38(6):907-15. doi: 10.1172/JCI103873.
6
The regulation of activity of phosphoribosyl-pyrophosphate amidotransferase by purine ribonacleotides: a potential feedback control of purine biosyntoesis.嘌呤核糖核苷酸对磷酸核糖焦磷酸酰胺转移酶活性的调节：嘌呤生物合成的一种潜在反馈控制。
J Biol Chem. 1959 Jun;234(6):1492-6.
7
Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects.正常人和痛风患者体内甘氨酸-1-C14、甘氨酸-2-C14和甘氨酸-N15掺入尿酸的情况。
Am J Med. 1958 Dec;25(6):917-32. doi: 10.1016/0002-9343(58)90063-9.
8
Inhibition of uric acid biosynthesis in birds by o-diazoacetyl-L-serine (azaserine) and 6-diazo-5-oxo-L-norleucine (DON).邻重氮乙酰基-L-丝氨酸（偶氮丝氨酸）和6-重氮-5-氧代-L-正亮氨酸（DON）对鸟类尿酸生物合成的抑制作用。
Am J Physiol. 1958 Oct;195(1):244-50. doi: 10.1152/ajplegacy.1958.195.1.244.
9
Failure to detect consistent overincorporation of glycine-1-C14 into uric acid in primary gout.在原发性痛风中未能检测到甘氨酸 -1-C14持续过度掺入尿酸。
Metabolism. 1958 Jul;7(4 Pt 1):376-7.
10
Pharmacological and initial therapeutic observations on 6-diazo-5-oxo-1-norleucine (DON) in human neoplastic disease.6-重氮-5-氧代-1-正亮氨酸（DON）在人类肿瘤疾病中的药理学及初步治疗观察
Cancer. 1957 Nov-Dec;10(6):1138-50. doi: 10.1002/1097-0142(195711/12)10:6<1138::aid-cncr2820100608>3.0.co;2-k.