Vogt U, Gürtler L, Cleve H
Blutspendedienst des Bayerischen, Roten Kreuzes, Institut München, Germany.
Electrophoresis. 1992 May;13(5):337-8. doi: 10.1002/elps.1150130168.
The inter-alpha-trypsin inhibitor (ITI) polymorphism was analyzed in an African Negroid population using polyacrylamide gel isoelectric focusing and subsequent immunoblotting. Gene frequencies of ITI1, ITI2, ITI3 and ITI4 were calculated to be 0.564, 0.083, 0.337 and 0.004, respectively. One unknown rare allele, ITI6, determines further phenotypes in combination with the alleles ITI1 and ITI3. Gene frequency of ITI6 was calculated to be 0.012. The common alleles are represented by ITI1 and ITI3. The allele distribution is therefore different from European and Asian populations.
采用聚丙烯酰胺凝胶等电聚焦和后续免疫印迹法，对非洲黑人种群中的α-胰蛋白酶抑制剂（ITI）多态性进行了分析。计算得出ITI1、ITI2、ITI3和ITI4的基因频率分别为0.564、0.083、0.337和0.004。一个未知的稀有等位基因ITI6与等位基因ITI1和ITI3组合可确定更多的表型。计算得出ITI6的基因频率为0.012。常见等位基因为ITI1和ITI3。因此，该等位基因分布与欧洲和亚洲人群不同。
