关于氢氧化甲基汞与甲钴胺的反应。

On the reaction of methylmercuric hydroxide with methylbabalamin.

作者信息

Chu V C, Gruenwedel D W

出版信息

Z Naturforsch C Biosci. 1976 Nov-Dec;31(11-12):753-5. doi: 10.1515/znc-1976-11-1225.

DOI:10.1515/znc-1976-11-1225

Abstract

The methylmercury-induced dealkylation of the corrinoid coenzyme methylcobalamin, yielding aquocobalamin and dimethylmercury as products, was studied spectrophotometrically at 350 nm using water as a solvent. Rate data were determined for the pH 7-9 region and also at pH 3.37. Evidence is provided which shows that CH3Hg+ serves as the species which accepts the methyl group and also that Hg2+ is methylated more rapidly than CH3Hg+ is.

摘要

使用水作为溶剂，在350 nm波长下通过分光光度法研究了甲基汞诱导的类咕啉辅酶甲钴胺的脱烷基化反应，该反应生成水合钴胺素和二甲基汞作为产物。测定了pH值在7至9范围内以及pH值为3.37时的速率数据。有证据表明，CH3Hg+是接受甲基的物种，并且Hg2+比CH3Hg+的甲基化速度更快。