Morris C E
Neurosciences, Loeb Institute, Ottawa Civic Hospital, Ontario, Canada.
Experientia. 1992 Sep 15;48(9):852-8. doi: 10.1007/BF02118418.
Single-channel recordings of dozens of cell types, including invertebrate (molluscan) and vertebrate heart cells, reveal stretch-sensitive ion channels. The physiological roles of these channels are undoubtedly diverse but it is usually assumed that the roles they play are related to the channels' mechanosensitive gating. Whether this assumption is valid remains to be seen. Attempts to connect the single-channel observations with the mechanical aspects of physiological or developmental processes are discussed. In the case of molluscan cells, recent work suggests that their stretch channels have physiological functions unrelated to mechanosensitive gating.
对包括无脊椎动物（软体动物）和脊椎动物心脏细胞在内的几十种细胞类型进行的单通道记录，揭示了拉伸敏感离子通道。这些通道的生理作用无疑是多种多样的，但通常认为它们所起的作用与通道的机械敏感门控有关。这一假设是否成立还有待观察。本文讨论了将单通道观测结果与生理或发育过程的力学方面联系起来的尝试。就软体动物细胞而言，最近的研究表明，它们的拉伸通道具有与机械敏感门控无关的生理功能。
