Minnunni M, Wolleb U, Mueller O, Pfeifer A, Aeschbacher H U
Nestec Ltd, Nestlé Research Centre, Vers-chez-les-Blanc, Lausanne, Switzerland.
Mutat Res. 1992 Oct;269(2):193-200. doi: 10.1016/0027-5107(92)90200-l.
A ternary antioxidant vitamin mix consisting of ascorbic acid, alpha-tocopherol and lecithin as well as a rosemary extract with carnosic acid and carnosol as the two major active ingredients were shown to exhibit strong antimutagenic effects in Ames tester strain TA102. This strain has been shown to be highly sensitive to reactive oxygen species. Mutagenicity was induced by the generation of oxygen radicals by tert-butyl-hydroperoxide (tBOOH) or hydrogen peroxide (H2O2); therefore, the antimutagenic property of the above substances was attributed to their antioxidant properties. In the case of the vitamin mix, ascorbic acid was held responsible for this inhibitory property, whereas for the rosemary extract carnosic acid was identified as the antimutagenic agent. Since oxygen radicals are known to be involved in the multiprocess of carcinogenicity, it is concluded that these antioxidants might exhibit anticarcinogenic properties.
由抗坏血酸、α-生育酚和卵磷脂组成的三元抗氧化维生素混合物，以及以鼠尾草酸和鼠尾草酚为两种主要活性成分的迷迭香提取物，在艾姆斯测试菌株TA102中显示出很强的抗诱变作用。该菌株已被证明对活性氧高度敏感。诱变是由叔丁基过氧化氢（tBOOH）或过氧化氢（H2O2）产生氧自由基诱导的；因此，上述物质的抗诱变特性归因于它们的抗氧化特性。就维生素混合物而言，抗坏血酸被认为具有这种抑制特性，而对于迷迭香提取物，鼠尾草酸被确定为抗诱变剂。由于已知氧自由基参与致癌的多过程，因此得出结论，这些抗氧化剂可能具有抗癌特性。
