Kaur I P, Saini A
University Institute of Pharmaceutical Sciences, Punjab University, 160014, Chandigarh, India.
Mutat Res. 2000 Oct 10;470(1):71-6. doi: 10.1016/s1383-5718(00)00096-6.
The effects of sesamol, a phenolic compound responsible for the high resistance of sesame oil to oxidative deterioration as compared with other vegetable oils, have been investigated after mutagen treatment in various strains of Salmonella typhimurium. Sesamol was shown to exhibit strong antimutagenic effects in the Ames tester strains TA100 and TA102. The TA102 strain has been shown to be highly sensitive to reactive oxygen species. Mutagenicity was induced by the generation of oxygen radicals by tert-butylhydroperoxide (t-BOOH) or hydrogen peroxide (H(2)O(2)); therefore, the antimutagenic property of sesamol was attributed to its antioxidant properties. The superoxide and hydroxyl radical scavenging capabilities have further been elucidated using in vitro test systems. It was further shown to have a desmutagenic effect on t-BOOH-induced mutagenesis in TA102 strain. Sesamol also inhibited the mutagenicity of sodium azide (Na-azide) in TA100 tester strain while it had no effect on nitroquinoline-N-oxide (NQNO)-induced mutagenesis in TA98 strain of Salmonella typhimurium. Since active oxygen species are involved in multiple stage processes of carcinogenicity, this compound may also exhibit anticarcinogenic properties.
芝麻酚是一种酚类化合物，与其他植物油相比，它使芝麻油具有高抗氧化性。在对多种鼠伤寒沙门氏菌菌株进行诱变处理后，研究了芝麻酚的作用。结果表明，芝麻酚在艾姆斯试验菌株TA100和TA102中表现出很强的抗诱变作用。TA102菌株已被证明对活性氧高度敏感。叔丁基过氧化氢（t-BOOH）或过氧化氢（H₂O₂）产生氧自由基可诱导致突变性；因此，芝麻酚的抗诱变特性归因于其抗氧化特性。使用体外测试系统进一步阐明了超氧化物和羟基自由基清除能力。进一步表明，它对TA102菌株中t-BOOH诱导的诱变具有去诱变作用。芝麻酚还抑制TA100测试菌株中叠氮化钠（NaN₃）的诱变性，而对鼠伤寒沙门氏菌TA98菌株中N-硝基喹啉-N-氧化物（NQNO）诱导的诱变没有影响。由于活性氧参与致癌作用的多个阶段过程，这种化合物也可能具有抗癌特性。
