Willems M, Moshage H, Fevery J, Yap S H
Department of Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium.
Neth J Med. 1992 Aug;41(1-2):36-43.
Until recently the diagnosis of non-A, non-B hepatitis was made by excluding other detectable viral infections of the liver. Progress in molecular biology made it possible to develop assays which can trace antibodies against the hepatitis C virus. This virus plays a major role in the pathogenesis of transfusion-related and sporadic non-A, non-B hepatitis and possibly of other liver diseases. Although the genome of a few isolates of the hepatitis C virus has already been decoded, the viral particles have not yet been visualized.
直到最近,非甲非乙型肝炎的诊断仍是通过排除其他可检测到的肝脏病毒感染来进行的。分子生物学的进展使得开发能够追踪抗丙型肝炎病毒抗体的检测方法成为可能。这种病毒在输血相关和散发性非甲非乙型肝炎以及可能的其他肝脏疾病的发病机制中起主要作用。尽管已经解码了几种丙型肝炎病毒分离株的基因组,但病毒颗粒尚未可视化。