Chai B, Meltzer H Y
Laboratory of Biological Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Neurosci Lett. 1992 Jun 8;140(1):47-50. doi: 10.1016/0304-3940(92)90678-z.
Previous studies have produced conflicting results concerning the effect of chronic oral vs. parenteral (i.p.) clozapine administration on dopamine (DA) release and metabolism in the striatum and nucleus accumbens (n. accumbens) of freely moving rats using in vivo microdialysis. In this study, parenteral chronic clozapine (20 mg/kg/day for 21 days, i.p.) had no effect on basal DA release and metabolism in either region. Chronic treatment with parenteral clozapine also did not reverse the decrease in DA release and metabolism in striatum and n. accumbens produced by apomorphine (100 micrograms/kg, s.c.). These results differ significantly from a previous report following i.p. clozapine and confirm the results previously reported with oral clozapine.
以往的研究对于长期口服与胃肠外（腹腔注射）给予氯氮平对自由活动大鼠纹状体和伏隔核中多巴胺（DA）释放及代谢的影响得出了相互矛盾的结果，这些研究采用了体内微透析技术。在本研究中，胃肠外长期给予氯氮平（20毫克/千克/天，共21天，腹腔注射）对这两个区域的基础DA释放及代谢均无影响。胃肠外给予氯氮平进行长期治疗也未能逆转由阿扑吗啡（100微克/千克，皮下注射）引起的纹状体和伏隔核中DA释放及代谢的降低。这些结果与之前腹腔注射氯氮平后的一份报告有显著差异，并证实了之前口服氯氮平所报告的结果。
