通过体内微透析研究慢性氯氮平和氟哌啶醇对大鼠纹状体和伏隔核中基础多巴胺释放及代谢的影响。
The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis.
作者信息
Ichikawa J, Meltzer H Y
机构信息
Laboratory of Biological Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, OH 44106.
出版信息
Eur J Pharmacol. 1990 Feb 13;176(3):371-4. doi: 10.1016/0014-2999(90)90033-3.
The effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. Chronic haloperidol (2 mg/kg X 21 days) but not chronic clozapine (20 mg/kg X 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. These results differ significantly from those previously reported with in vivo voltammetry. Possible explanations are discussed.
使用体内微透析技术，研究了氯氮平和氟哌啶醇长期治疗对清醒、自由活动大鼠纹状体和伏隔核中多巴胺基础释放及代谢的影响。长期给予氟哌啶醇（2毫克/千克×21天），而非氯氮平（20毫克/千克×21天），会降低纹状体和伏隔核中多巴胺的基础释放及代谢。这些结果与先前用体内伏安法报道的结果有显著差异。文中讨论了可能的解释。
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