[卡那霉素向阿米卡星可能的生物转化研究]
[Study of possible biological transformation of kanamycin to amikacin].
作者信息
Vikhanskiĭ Iu D, Iarulin V R, Zhdanovich Iu V, Bartoshevich Iu E, Esipova V V, Nasonova L I
出版信息
Antibiot Khimioter. 1992 Jun;37(6):10-2.
PMID:1384450
Abstract
For transformation of kanamycin A (Km) to amikacin (Ak) with acylating enzymes from B. circulans, a culture producing butirosin (Btn), cellular and acellular conversion systems and methods for chemical and biological identification of Km, Ak and Btn were developed. The level of conversion of Km to Ak in vivo and in vitro did not exceed 2 per cent.
摘要
为了利用环状芽孢杆菌的酰化酶将卡那霉素A（Km）转化为阿米卡星（Ak），开发了一种生产丁胺卡那霉素（Btn）的培养物、细胞和无细胞转化系统以及用于化学和生物学鉴定Km、Ak和Btn的方法。体内和体外Km向Ak的转化率均不超过2%。
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