Nam D H, Ryu D D
Antimicrob Agents Chemother. 1985 May;27(5):798-801. doi: 10.1128/AAC.27.5.798.
The relationship between butirosin biosynthesis and certain biochemical characteristics related to sporulation in a strain of Bacillus circulans NRRL B-3313 was examined. The cellular content of dipicolinic acid increased while the amount of poly-beta-hydroxybutyrate decreased with changes in antibiotic productivity. Oligosporogenous mutants failed to synthesize the antibiotic and to degrade poly-beta-hydroxybutyrate. These observations suggest that spore formation may be related to antibiotic production in this strain of B. circulans.
研究了环状芽孢杆菌NRRL B - 3313菌株中丁胺卡那霉素生物合成与某些与孢子形成相关的生化特性之间的关系。随着抗生素产量的变化,吡啶二羧酸的细胞含量增加,而聚-β-羟基丁酸酯的量减少。寡孢子形成突变体无法合成抗生素并降解聚-β-羟基丁酸酯。这些观察结果表明,在这种环状芽孢杆菌菌株中,孢子形成可能与抗生素产生有关。