Janot C, Couroucé A M, Boudart D, Cotte C, Elghouzzi M H, Jullien A M, Lemaire J M, Maisonneuve P, Maniez-Montreuil M, Mattlinger B
CRTSH Nancy.
Rev Fr Transfus Hemobiol. 1992 Jul;35(3):171-82. doi: 10.1016/s1140-4639(05)80120-0.
Anti-HCV systematic screening on blood donation was mandatory in France since first of March 1991. Two laboratories (Ortho-Chiron and Abbott) have introduced in Europe successively two kinds of hepatitis C positive diagnosis with 1st and 2nd generation ELISA screening and confirmatory assays. The aim of this multicentric study was to evaluated the sensibility and specificity of these tests. For that, they used 10,090 blood sera. As a result we have seen that the new "second generation" screening assays have a higher sensitivity without less of specificity for the confirmatory tests.
自1991年3月1日起，法国强制要求对献血者进行抗丙型肝炎病毒（Anti-HCV）系统筛查。两家实验室（奥索-希龙公司和雅培公司）先后在欧洲推出了两种丙型肝炎阳性诊断方法，采用第一代和第二代酶联免疫吸附测定（ELISA）筛查及确证试验。这项多中心研究的目的是评估这些检测方法的敏感性和特异性。为此，他们使用了10090份血清样本。结果我们发现，新的“第二代”筛查试验具有更高的敏感性，同时确证试验的特异性并未降低。
