Kummer W, Fischer A, Mundel P, Mayer B, Hoba B, Philippin B, Preissler U
Institute for Anatomy and Cell Biology, Ruprecht-Karls-University, Heidelberg, Germany.
Neuroreport. 1992 Jul;3(7):653-5. doi: 10.1097/00001756-199207000-00028.
We investigated the possibility of nitric oxide (NO), a powerful vasodilator agent, being synthesized by perivascular nerve fibres. Immunoreactivity and catalytic activity of the NO synthesizing enzyme, NO synthase (NOS), were demonstrated in perivascular nerve fibres of blood vessels receiving autonomic vasodilator innervation, but not of those innervated exclusively by vasoconstrictor nerve fibres. Double-labelling techniques allowed identification of NOS-containing nerve fibres as belonging to the vasoactive intestinal peptide (VIP)/acetylcholine-containing class whereas noradrenergic and substance P-containing perivascular fibres were devoid of NOS. We suggest that, in addition to its endothelial source, NO is a neuronal co-mediator of VIP/cholinergic vasodilation.
我们研究了强效血管舒张剂一氧化氮（NO）由血管周围神经纤维合成的可能性。在接受自主神经舒张神经支配的血管的血管周围神经纤维中，一氧化氮合成酶（NOS）的免疫反应性和催化活性得到了证实，但在仅由血管收缩神经纤维支配的血管周围神经纤维中未得到证实。双重标记技术可将含NOS的神经纤维鉴定为属于含血管活性肠肽（VIP）/乙酰胆碱的类别，而含去甲肾上腺素能和P物质的血管周围纤维则不含NOS。我们认为，除了其内皮来源外，NO还是VIP/胆碱能血管舒张的神经元共同介质。
