Perez-Oteyza J, Roldan E, Brieva J A, Cancelas J A, Garcia-Larana J, Odriozola J, Hernandez Jodra M, Navarro J L
Department of Haematology, Hospital Ramon y Cajal, Madrid, Spain.
Bone Marrow Transplant. 1992 Sep;10(3):297-9.
A 20-year-old male with severe bone marrow failure associated with paroxysmal nocturnal haemoglobinuria (PNH) underwent an allogeneic bone marrow transplantation (BMT). Flow cytometric analysis of phosphatidylinositol (PI) anchored membrane proteins prior to BMT showed a markedly reduced expression of monocyte CD14 and neutrophil CD16 molecules. On day +17 after BMT expression of both antigens reached normal values and remained stable throughout a follow-up period of 10 months, thus confirming the eradication of the PNH clone. To date, this is the first case in which normal expression of PI-anchored proteins after BMT is reported.
一名20岁男性，患有与阵发性夜间血红蛋白尿（PNH）相关的严重骨髓衰竭，接受了异基因骨髓移植（BMT）。骨髓移植前对磷脂酰肌醇（PI）锚定膜蛋白进行的流式细胞术分析显示，单核细胞CD14和中性粒细胞CD16分子的表达明显降低。骨髓移植后第17天，两种抗原的表达均达到正常值，并在10个月的随访期内保持稳定，从而证实了PNH克隆已被根除。迄今为止，这是首例报道骨髓移植后PI锚定蛋白正常表达的病例。
