Endo Y, Kikuchi T, Takeda Y, Nitta Y, Rikiishi H, Kumagai K
Department of Pharmacology, School of Dentistry, Tohoku University, Sendai, Japan.
Immunol Lett. 1992 Jun;33(1):9-13. doi: 10.1016/0165-2478(92)90086-4.
Histamine and putrescine (a precursor of polyamines) are formed by histidine decarboxylase (HDC) and ornithine decarboxylase (ODC), respectively. Within a few hours after injection of a lipopolysaccharide (LPS) into mice, HDC is induced in the liver, spleen, lung and bone marrow, and ODC is induced in the liver, spleen and bone marrow. Since LPS is known to stimulate the production of various cytokines, the abilities of various cytokines to induce HDC and ODC in the tissues of mice were examined. IL-2, IL-6, IL-8, IFN gamma and M-CSF were ineffective. IL-1 alpha, IL-1 beta, TNF alpha and TNF beta induced HDC and ODC, as does LPS. On the other hand, GM-CSF and G-CSF induced HDC and ODC only in the spleen and bone marrow within a few hours after their injection. These results suggest that, in addition to their roles in inflammation or immune responses, HDC and ODC are also involved in an early stage of hematopoiesis.
组胺和腐胺（多胺的前体）分别由组氨酸脱羧酶（HDC）和鸟氨酸脱羧酶（ODC）生成。给小鼠注射脂多糖（LPS）后的数小时内，肝脏、脾脏、肺和骨髓中会诱导产生HDC，而肝脏、脾脏和骨髓中会诱导产生ODC。由于已知LPS会刺激多种细胞因子的产生，因此研究了多种细胞因子在小鼠组织中诱导HDC和ODC的能力。白细胞介素-2（IL-2）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、干扰素γ（IFNγ）和巨噬细胞集落刺激因子（M-CSF）均无作用。白细胞介素-1α（IL-1α）、白细胞介素-1β（IL-1β）、肿瘤坏死因子α（TNFα）和肿瘤坏死因子β（TNFβ）与LPS一样，可诱导HDC和ODC。另一方面，粒细胞-巨噬细胞集落刺激因子（GM-CSF）和粒细胞集落刺激因子（G-CSF）在注射后数小时内仅在脾脏和骨髓中诱导HDC和ODC。这些结果表明，除了在炎症或免疫反应中的作用外，HDC和ODC还参与造血的早期阶段。
