Takamatsu S, Nakano K
Nagoya University BioScience Center, Japan.
Biosci Biotechnol Biochem. 1994 Oct;58(10):1918-9. doi: 10.1271/bbb.58.1918.
Histamine may be involved in the regulation of hematopoiesis. However, it remained obscure what kind of cells are responsible for its synthesis in bone marrow (BM). In this study, a pure population of macrophages were raised from BM of W/Wv mice, which are genetically deficient in mast cells. The addition of Escherichia coli lipopolysaccharide (LPS) or murine recombinant granulocyte/macrophage colony-stimulating factor (mrGM-CSF) alone had essentially no effect on histamine synthesis. However, the latter rendered the cells responsive to LPS, leading to a marked increase in HDC-dependent histamine synthesis.
组胺可能参与造血调节。然而，骨髓中负责其合成的是何种细胞仍不清楚。在本研究中，从肥大细胞基因缺陷的W/Wv小鼠的骨髓中培养出了纯巨噬细胞群体。单独添加大肠杆菌脂多糖（LPS）或小鼠重组粒细胞/巨噬细胞集落刺激因子（mrGM-CSF）对组胺合成基本没有影响。然而，后者使细胞对LPS产生反应，导致依赖组氨酸脱羧酶（HDC）的组胺合成显著增加。
