变应性脑脊髓炎作为多发性硬化症的实验模型。
Allergic encephalomyelitis as an experimental model for multiple sclerosis.
作者信息
ROBOZ-EINSTEIN E
出版信息
Calif Med. 1959 Oct;91(4):204-6.
Abstract
Proteins isolated from bovine spinal cord exhibit encephalitogenic activity. One of these proteins, of collagen type, was found to be homogeneous. This protein, however, is not considered to be the main encephalitogenic agent; other proteins with different physicochemical characteristics were found to possess higher activity. The use of these proteins will make it possible to study the allergic nature of the experimental disease and may lead to disclosure of the underlying mechanism of the pathological process not only in allergic encephalomyelitis but in multiple sclerosis.
摘要
从牛脊髓中分离出的蛋白质具有致脑炎活性。其中一种胶原蛋白类型的蛋白质被发现是均质的。然而，这种蛋白质不被认为是主要的致脑炎因子；已发现其他具有不同物理化学特性的蛋白质具有更高的活性。使用这些蛋白质将有可能研究实验性疾病的过敏性本质，并可能不仅揭示变应性脑脊髓炎，而且揭示多发性硬化症病理过程的潜在机制。
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