Teunissen M B
Department of Dermatology, University of Amsterdam, The Netherlands.
J Invest Dermatol. 1992 Nov;99(5):77S-79S. doi: 10.1111/1523-1747.ep12669802.
Interaction of T-cell antigen receptors with antigen/major histocompatibility complex (MHC) molecule complexes on antigen-presenting cells (APC) leads to T-cell activation. Additional interaction between adhesion molecules on the APC and their ligands on T cells is required for optimal T-cell activation. In vitro cultured human epidermal Langerhans cells (cLC) are powerful APC that express adhesion molecules LFA-3 and ICAM-1. Both molecules on cLC serve a functional role in the generation of a T-cell response.
T细胞抗原受体与抗原呈递细胞（APC）上的抗原/主要组织相容性复合体（MHC）分子复合物相互作用会导致T细胞活化。APC上的黏附分子与其T细胞上的配体之间的额外相互作用对于最佳T细胞活化是必需的。体外培养的人表皮朗格汉斯细胞（cLC）是强大的APC，可表达黏附分子LFA-3和ICAM-1。cLC上的这两种分子在T细胞反应的产生中均发挥功能性作用。
