Hatjis C G, Kofinas A D, Greelish J P, Swain M, Rose J C
Department of Obstetrics and Gynecology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Am J Perinatol. 1992 Jul;9(4):275-8. doi: 10.1055/s-2007-994788.
Atrial natriuretic factor (ANF) is a hormone that regulates fluid and electrolyte homeostasis. Increased intra-atrial pressure or atrial distention, which might occur secondary to intravascular volume expansion, stimulate the secretion of ANF by human atrial myocytes. During normal human pregnancy, there is a progressive increase in total intravascular fluid volume. Thus, we asked the following question: Does this physiologic adaptation to pregnancy result in an increase in ANF concentrations? Concentrations of alpha-human ANF (alpha-hANF) were measured by a specific radioimmunoassay in venous blood samples obtained longitudinally in the first, second, and third trimesters of pregnancy, during the intrapartum period, in the early postpartum period, and 6 to 8 weeks postpartum from 11 normal women who had no antepartum, intrapartum, or postpartum complications. Maternal circulating alpha-hANF levels were not different from those seen in the nonpregnant state. However, higher alpha-hANF concentrations were noted in the early postpartum period. Although the hypervolemia of normal pregnancy is not associated with higher alpha-hANF concentrations, other possibilities (such as increased ANF clearance, dilutional effects) need to be investigated. Finally, the etiology for the transient increase in alpha-hANF levels in the early postpartum period remains to be elucidated.
心房利钠因子（ANF）是一种调节体液和电解质平衡的激素。血管内容量扩张继发引起的心房内压升高或心房扩张，会刺激人心房肌细胞分泌ANF。在正常人类妊娠期间，血管内总体液量会逐渐增加。因此，我们提出了以下问题：这种对妊娠的生理适应性变化是否会导致ANF浓度升高？通过特定的放射免疫分析法，对11名无产前、产时或产后并发症的正常女性在妊娠第一、第二和第三孕期、产时、产后早期以及产后6至8周纵向采集的静脉血样本中的α-人ANF（α-hANF）浓度进行了测量。母体循环中的α-hANF水平与非妊娠状态下的水平无差异。然而，产后早期的α-hANF浓度较高。尽管正常妊娠的血容量过多与较高的α-hANF浓度无关，但其他可能性（如ANF清除增加、稀释效应）仍需研究。最后，产后早期α-hANF水平短暂升高的病因仍有待阐明。
