Marlettini M G, Cassani A, Boschi S, Morselli Labate A M, Crippa S, Borghi C, Contarini A, Rusticali A G, Orlandi C
II Clinica Ostetrica e Ginecologica, Universita' di Bologna, Italy.
Clin Exp Hypertens A. 1989;11(4):531-52. doi: 10.3109/10641968909035359.
The atrial natriuretic factor (ANF) and parameters related to renal sodium handling and renal function were evaluated in 92 normotensive pregnant women at different gestational ages (1st group: 7th-13th week, 2nd group: 14th-20th week; 3rd group: 21st-27th week; 4th group: 28th-34th week; 5th group: greater than 34th week), in 15 normotensive non-pregnant women and in 15 normotensive women 6 days after spontaneous delivery at the end of a normal pregnancy. ANF did not differ significantly between the 5 groups of pregnant women while, concurrently with a further increase in plasma volume (as shown by our data) it was significantly higher in late pregnancy (3rd and 5th groups) than in the non-pregnant women. ANF in post-partum women was significantly higher than in non-pregnant and pregnant women. Only in post-partum women was ANF significantly directly related to sodium excretion. Even though ANF does not seem to play an important role in water and sodium excretion in pregnancy in comparison with other hormones such as progesterone, oestriol and aldosterone, the higher levels of ANF in late pregnancy probably represent a compensatory increase when a given threshold of plasma volume (and therefore of atrial stretch) is reached. However ANF does seem to play a more important role in the induction of diuresis and natriuresis in early puerperium.
对92名不同孕周的血压正常孕妇（第1组：第7 - 13周；第2组：第14 - 20周；第3组：第21 - 27周；第4组：第28 - 34周；第5组：大于第34周）、15名血压正常的未孕女性以及15名血压正常的女性在正常妊娠结束自然分娩6天后进行了心房利钠因子（ANF）以及与肾脏钠处理和肾功能相关参数的评估。5组孕妇之间的ANF无显著差异，而在血浆容量进一步增加的同时（如我们的数据所示），妊娠晚期（第3组和第5组）的ANF显著高于未孕女性。产后女性的ANF显著高于未孕和孕期女性。仅在产后女性中，ANF与钠排泄显著直接相关。尽管与孕酮、雌三醇和醛固酮等其他激素相比，ANF在孕期水钠排泄中似乎不发挥重要作用，但妊娠晚期较高水平的ANF可能代表当达到血浆容量（以及因此心房牵张）的给定阈值时的一种代偿性增加。然而，ANF在产褥早期利尿和利钠诱导中似乎发挥更重要的作用。
