吗啡对大鼠胆碱能受体和多巴胺D2受体激活诱导的打哈欠的抑制作用。
Inhibitory effect of morphine on yawning induced by cholinoceptor and dopamine D2 receptor activation in rats.
作者信息
Zarrindast M R, Jamshidzadeh A
机构信息
Department of Pharmacology, Medical Faculty, University of Tehran, Iran.
出版信息
Br J Pharmacol. 1992 Mar;105(3):675-8. doi: 10.1111/j.1476-5381.1992.tb09037.x.
Abstract
- Bromocriptine (2, 4 and 8 mg kg-1, i.p.), physostigmine (0.05, 0.1 and 0.2 mg kg-1, i.p.) and pilocarpine (1, 3 and 5 mg kg-1, i.p.) induced dose-dependent yawning in rats. 2. These responses were reduced in a dose-dependent manner by pretreatment with morphine. 3. The inhibitory effect of morphine was reversed by naloxone. 4. Naloxone alone induced slight but significant yawning. 5. The present results suggest that morphine inhibits yawning in rats at an opiate receptor downstream from the sites at which cholinoceptor and dopamine D2 activation induce yawning. The anatomical location of these sites remains to be established.
摘要
- 溴隐亭（2、4和8毫克/千克，腹腔注射）、毒扁豆碱（0.05、0.1和0.2毫克/千克，腹腔注射）和毛果芸香碱（1、3和5毫克/千克，腹腔注射）可诱导大鼠出现剂量依赖性打哈欠。2. 吗啡预处理可使这些反应呈剂量依赖性降低。3. 纳洛酮可逆转吗啡的抑制作用。4. 单独使用纳洛酮可诱导轻微但显著的打哈欠。5. 目前的结果表明，吗啡在胆碱能受体和多巴胺D2激活诱导打哈欠的位点下游的阿片受体处抑制大鼠打哈欠。这些位点的解剖位置仍有待确定。
相似文献
1
Inhibitory effect of morphine on yawning induced by cholinoceptor and dopamine D2 receptor activation in rats.吗啡对大鼠胆碱能受体和多巴胺D2受体激活诱导的打哈欠的抑制作用。
Br J Pharmacol. 1992 Mar;105(3):675-8. doi: 10.1111/j.1476-5381.1992.tb09037.x.
2
Interactions of drugs acting on central dopamine receptors and cholinoceptors on yawning responses in the rat induced by apomorphine, bromocriptine or physostigmine.作用于中枢多巴胺受体和胆碱能受体的药物对阿扑吗啡、溴隐亭或毒扁豆碱诱导的大鼠打哈欠反应的相互作用。
Br J Pharmacol. 1989 Apr;96(4):843-8. doi: 10.1111/j.1476-5381.1989.tb11893.x.
3
Multifocal sites of action involved in dopaminergic-cholinergic neuronal interactions in yawning.打哈欠过程中多巴胺能-胆碱能神经元相互作用所涉及的多焦点作用位点。
Psychopharmacology (Berl). 1988;95(1):34-7. doi: 10.1007/BF00212762.
4
Yawning induced by apomorphine, physostigmine or pilocarpine is potentiated by dihydropyridine calcium channel blockers.
Psychopharmacology (Berl). 1990;100(2):168-72. doi: 10.1007/BF02244401.
5
Role of dopamine receptors in the dual effect of naloxone on quinpirole-induced yawning in morphine pretreated rats.多巴胺受体在纳洛酮对吗啡预处理大鼠中喹吡罗诱导打哈欠的双重作用中的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1993 May;347(5):478-82. doi: 10.1007/BF00166738.
6
[Effects of bifemelane on central dopaminergic and cholinergic systems in rats].[比芬美兰对大鼠中枢多巴胺能和胆碱能系统的影响]
Yakubutsu Seishin Kodo. 1988 Dec;8(4):463-70.
7
Two inbred rat sublines that differ in spontaneous yawning behavior also differ in their responses to cholinergic and dopaminergic drugs.
Behav Brain Res. 1993 Sep 30;56(2):155-9. doi: 10.1016/0166-4328(93)90033-m.
8
Behavioral effects of dilazep on cholinergic, dopaminergic, and purinergic systems in the rat.双嘧达莫对大鼠胆碱能、多巴胺能和嘌呤能系统的行为学影响。
Pharmacol Biochem Behav. 1992 Nov;43(3):673-6. doi: 10.1016/0091-3057(92)90394-u.
9
Modification of apomorphine-, physostigmine- and pilocarpine-induced yawning after long-term treatment with neuroleptic or cholinergic agents.长期使用抗精神病药物或胆碱能药物治疗后对阿扑吗啡、毒扁豆碱和毛果芸香碱诱导的打哈欠的影响。
Arch Int Pharmacodyn Ther. 1984 Oct;271(2):180-8.
10
Effects of stress on drug-induced yawning: constant vs. intermittent stress.
Physiol Behav. 1995 Jul;58(1):181-4. doi: 10.1016/0031-9384(95)00043-i.
引用本文的文献
1
Turmeric active substance, curcumin, enhanced apomorphine-induced yawning in rats.姜黄活性物质姜黄素可增强阿扑吗啡诱导的大鼠打哈欠行为。
Avicenna J Phytomed. 2013 Summer;3(3):231-7.
2
Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice.多巴胺D2样激动剂的促勃起作用是由大鼠和小鼠体内的D3受体介导的。
J Pharmacol Exp Ther. 2009 Apr;329(1):210-7. doi: 10.1124/jpet.108.144048. Epub 2009 Jan 9.
3
Drug-induced yawning: a review of the French pharmacovigilance database.药物性哈欠：法国药物警戒数据库综述
Drug Saf. 2007;30(4):327-31. doi: 10.2165/00002018-200730040-00005.
4
Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior.多巴胺激动剂诱导大鼠打哈欠：一种由多巴胺D3受体介导的行为。
J Pharmacol Exp Ther. 2005 Jul;314(1):310-9. doi: 10.1124/jpet.105.085472. Epub 2005 Apr 15.
5
Effects of GABAergic drugs on physostigmine-induced yawning in rats.γ-氨基丁酸能药物对毒扁豆碱诱导大鼠打哈欠的影响。
Psychopharmacology (Berl). 1995 Dec;122(3):297-300. doi: 10.1007/BF02246551.
6
Effects of SR 48692, a selective non-peptide neurotensin receptor antagonist, on two dopamine-dependent behavioural responses in mice and rats.选择性非肽类神经降压素受体拮抗剂SR 48692对小鼠和大鼠两种多巴胺依赖性行为反应的影响。
Psychopharmacology (Berl). 1994 Oct;116(2):237-41. doi: 10.1007/BF02245067.
本文引用的文献
1
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.生物材料中的3',5'-磷酸腺苷。I. 环3',5'-核苷酸磷酸二酯酶的纯化及性质，以及用该酶鉴定人尿中的3',5'-磷酸腺苷
J Biol Chem. 1962 Apr;237:1244-50.
2
Yawning.打哈欠。
J Neurol Neurosurg Psychiatry. 1958 Aug;21(3):203-9. doi: 10.1136/jnnp.21.3.203.
3
Direct evidence for involvement of dopaminergic inhibition and cholinergic activation in yawning.多巴胺能抑制和胆碱能激活参与打哈欠的直接证据。
Psychopharmacology (Berl). 1980 Jan;67(1):39-43. doi: 10.1007/BF00427593.
4
The role of dopaminergic receptors in the behavioral effects induced by lisuride in male rats.多巴胺能受体在利苏瑞肽对雄性大鼠行为影响中的作用。
Psychopharmacology (Berl). 1983;80(1):38-42. doi: 10.1007/BF00427492.
5
Opioid regulation of CNS dopaminergic pathways: a review of methodology, receptor types, regional variations and species differences.阿片类物质对中枢神经系统多巴胺能通路的调节：方法学、受体类型、区域差异及物种差异综述
Peptides. 1983 Sep-Oct;4(5):595-601. doi: 10.1016/0196-9781(83)90003-7.
6
Morphine and nigrostriatal function in the rat and mouse: the role of nigral and striatal opiate receptors.
Neuropharmacology. 1982 Dec;21(12):1305-10. doi: 10.1016/0028-3908(82)90138-1.
7
Actions of mu, kappa, sigma, delta and agonist/antagonist opiates on striatal dopaminergic function.μ、κ、σ、δ阿片受体及激动剂/拮抗剂类阿片药物对纹状体多巴胺能功能的作用。
J Pharmacol Exp Ther. 1980 Dec;215(3):697-703.
8
Differential effects of caffeine on dihydroxyphenylacetic acid concentrations in various rat brain dopaminergic structures.
J Pharm Pharmacol. 1984 Jul;36(7):458-60. doi: 10.1111/j.2042-7158.1984.tb04425.x.
9
Effects of apomorphine, TL-99 and 3-PPP on yawning in rats.
Neuropharmacology. 1984 Jan;23(1):19-22. doi: 10.1016/0028-3908(84)90211-9.
10
Pharmacological characteristics of dopamine receptors involved in the dual effect of dopamine agonists on yawning behaviour in rats.多巴胺受体的药理学特性与多巴胺激动剂对大鼠打哈欠行为的双重作用有关。
Eur J Pharmacol. 1983 Oct 28;94(3-4):271-80. doi: 10.1016/0014-2999(83)90416-8.
Zotero 插件