吗啡对大鼠胆碱能受体和多巴胺D2受体激活诱导的打哈欠的抑制作用。
Inhibitory effect of morphine on yawning induced by cholinoceptor and dopamine D2 receptor activation in rats.
作者信息
Zarrindast M R, Jamshidzadeh A
机构信息
Department of Pharmacology, Medical Faculty, University of Tehran, Iran.
出版信息
Br J Pharmacol. 1992 Mar;105(3):675-8. doi: 10.1111/j.1476-5381.1992.tb09037.x.
Abstract
- Bromocriptine (2, 4 and 8 mg kg-1, i.p.), physostigmine (0.05, 0.1 and 0.2 mg kg-1, i.p.) and pilocarpine (1, 3 and 5 mg kg-1, i.p.) induced dose-dependent yawning in rats. 2. These responses were reduced in a dose-dependent manner by pretreatment with morphine. 3. The inhibitory effect of morphine was reversed by naloxone. 4. Naloxone alone induced slight but significant yawning. 5. The present results suggest that morphine inhibits yawning in rats at an opiate receptor downstream from the sites at which cholinoceptor and dopamine D2 activation induce yawning. The anatomical location of these sites remains to be established.
摘要
- 溴隐亭（2、4和8毫克/千克，腹腔注射）、毒扁豆碱（0.05、0.1和0.2毫克/千克，腹腔注射）和毛果芸香碱（1、3和5毫克/千克，腹腔注射）可诱导大鼠出现剂量依赖性打哈欠。2. 吗啡预处理可使这些反应呈剂量依赖性降低。3. 纳洛酮可逆转吗啡的抑制作用。4. 单独使用纳洛酮可诱导轻微但显著的打哈欠。5. 目前的结果表明，吗啡在胆碱能受体和多巴胺D2激活诱导打哈欠的位点下游的阿片受体处抑制大鼠打哈欠。这些位点的解剖位置仍有待确定。
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