Baggio G, Ferrari F
Psychopharmacology (Berl). 1983;80(1):38-42. doi: 10.1007/BF00427492.
Lisuride increased the incidence of stretching and yawning (SY) as well as of penile erection (PE) and elicited stereotyped behavior (SB), aggressive behavior and mounting in male rats, depending on the dose used. SY was prevented by two dopaminergic antagonists, haloperidol and sulpiride, but not by methysergide, a serotoninergic antagonist, while PE was antagonized by all three drugs. With regard to SB, aggressive behavior and mounting, all three were suppressed by haloperidol; sulpiride, while partially antagonizing aggressiveness, failed to affect SB and mounting; methysergide did not significantly influence any of the three. This suggests that lisuride principally affects the dopaminergic system. Although further detailed studies are required to elucidate which type of the complex population of DA-receptors is involved in each kind of behavior, we suggest that SY at least is due to the activation by lisuride of presynaptic DA-receptors.
根据所用剂量，利苏瑞得增加了雄性大鼠伸展和打哈欠（SY）以及阴茎勃起（PE）的发生率，并引发刻板行为（SB）、攻击行为和骑跨行为。两种多巴胺能拮抗剂氟哌啶醇和舒必利可预防SY，但5-羟色胺能拮抗剂美西麦角则不能，而PE可被这三种药物拮抗。关于SB、攻击行为和骑跨行为，氟哌啶醇可抑制这三种行为；舒必利虽然部分拮抗攻击性，但对SB和骑跨行为没有影响；美西麦角对这三种行为均无显著影响。这表明利苏瑞得主要影响多巴胺能系统。尽管需要进一步详细研究以阐明哪种类型的复杂多巴胺受体群体参与了每种行为，但我们认为至少SY是由于利苏瑞得激活了突触前多巴胺受体所致。
