Wilson M G, Chan L S, Herbert W S
Genetics Division, Los Angeles County-University of Southern California Medical Center.
Teratology. 1992 Mar;45(3):285-92. doi: 10.1002/tera.1420450307.
The birth prevalence of Down syndrome (DS), although decreasing in parts of the world, is not known in many specific subpopulations. The rate of DS for live births was determined for a 15-year period (1974-1988) at the Los Angeles County-University of Southern California Medical Center, which is a large public hospital serving a predominantly Latino population. DS was ascertained primarily by clinical monitoring of newborn infants. The overall rate of DS was 1.60/1,000 live births and had minimal fluctuation throughout the 15 years. The rate of DS for Latino births was 1.69/1,000 live births, 1.67 when adjusted for maternal age, and 1.75 when corrected for prenatal diagnosis. The high rate of DS in the Latino population was associated with advanced maternal ages and increased maternal-age specific rates for DS, especially in the age ranges of 30 to 34 and 40 to 44 years, when compared with other studies.
唐氏综合征（DS）的出生患病率在世界部分地区虽呈下降趋势，但许多特定亚人群中的患病率仍不为人知。我们确定了洛杉矶县 - 南加州大学医学中心15年期间（1974 - 1988年）活产婴儿的唐氏综合征发生率，该中心是一家主要服务拉丁裔人群的大型公立医院。唐氏综合征主要通过对新生儿的临床监测来确定。唐氏综合征的总体发生率为每1000例活产中有1.60例，在这15年中波动极小。拉丁裔婴儿的唐氏综合征发生率为每1000例活产中有1.69例，经产妇年龄调整后为1.67例，经产前诊断校正后为1.75例。与其他研究相比，拉丁裔人群中唐氏综合征的高发生率与产妇高龄以及特定产妇年龄的唐氏综合征发生率增加有关，尤其是在30至34岁和40至44岁年龄范围内。
