Trimble B K, Baird P A
Am J Med Genet. 1978;2(1):1-5. doi: 10.1002/ajmg.1320020102.
Maternal age-specific risks of giving birth to a child with the Down syndrome (DS) are given by single-year age intervals. Such data are of value for more precise genetic counseling and in cost-benefit analyses of prenatal diagnosis programs. The data were obtained by linking records of children with DS at the British Columbia Health Surveillance Registry ( BCHSR ) to the appropriate birth registrations to derive maternal ages. The data related to 519 affected children out of a total of 354,880 live births in British Columbia between 1961 and 1970. The results, which are based on a high level of ascertainment, are compared to those reported in the only other published study relating to risks by single-year maternal age groupings, where completeness of ascertainment was estimated to be only 38%.
唐氏综合征（DS）患儿的母亲年龄特异性生育风险按单一年龄间隔给出。此类数据对于更精确的遗传咨询以及产前诊断项目的成本效益分析具有价值。这些数据是通过将不列颠哥伦比亚省健康监测登记处（BCHSR）的唐氏综合征患儿记录与相应的出生登记相链接以得出母亲年龄而获得的。数据涉及1961年至1970年间不列颠哥伦比亚省354,880例活产中的519名患病儿童。基于高确诊率得出的结果与另一项唯一已发表的按母亲单一年龄分组的风险研究报告结果进行了比较，在该研究中，确诊的完整性估计仅为38%。
