Gomita Y, Eto K, Furuno K, Mimaki Y, Araki Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
J Pharm Sci. 1992 Mar;81(3):228-31. doi: 10.1002/jps.2600810308.
Influences of acute exposure to cigarette smoke on plasma concentrations of nicorandil administered orally and parenterally were investigated in rats by HPLC. The animals were exposed to tobacco smoke of two kinds of cigarettes using a smoking machine (i.e., the cigarette smoke contained either low or high nicotine and tar). The plasma concentration of nicorandil administered orally at a dose of 10 mg/kg had a lower absorption phase in two cigarette smoke-exposed groups, particularly in the high nicotine and tar-containing cigarette smoke-exposed group, compared with the nonsmoking control group. The AUC and MRT values in a high nicotine and tar-containing cigarette smoke-exposed group were lower and higher, respectively, than in the nonsmoking control group. However, there was no marked difference in nicorandil plasma concentrations between the cigarette smoke-exposed group and the nonsmoking control group when nicorandil was administered ip or iv at a dose of 5 mg/kg. These results suggest that cigarette smoke exposure causes the suppression or delay of absorption of nicorandil from the gastrointestinal tract.
通过高效液相色谱法（HPLC）研究了急性暴露于香烟烟雾对大鼠口服和非肠道给药尼可地尔血浆浓度的影响。使用吸烟机使动物暴露于两种香烟的烟雾中（即，香烟烟雾中尼古丁和焦油含量分别为低或高）。与非吸烟对照组相比，在两个香烟烟雾暴露组中，以10mg/kg剂量口服给药的尼可地尔血浆浓度具有较低的吸收相，尤其是在高尼古丁和焦油含量的香烟烟雾暴露组中。高尼古丁和焦油含量的香烟烟雾暴露组中的AUC和MRT值分别低于和高于非吸烟对照组。然而，当以5mg/kg剂量腹腔注射或静脉注射尼可地尔时，香烟烟雾暴露组和非吸烟对照组之间的尼可地尔血浆浓度没有显著差异。这些结果表明，暴露于香烟烟雾会导致尼可地尔从胃肠道的吸收受到抑制或延迟。
