Gomita Y, Eto K, Furuno K, Araki Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
J Pharm Sci. 1992 Nov;81(11):1132-5. doi: 10.1002/jps.2600811118.
Influences of exposure to standard- (containing nicotine and tar) and nicotine-reduced-cigarette smoke on the pharmacokinetics of theophylline (20 mg/kg, per os) and cimetidine (50 mg/kg, per os) were investigated in rats. Animals were exposed to standard- or nicotine-reduced-cigarette smoke for 8 min with a "smoking machine". In control rats, theophylline concentrations in plasma increased rapidly, peaked 2 h later, and then decreased gradually. Concentrations of theophylline in plasma of rats exposed to standard- and nicotine-reduced-cigarette smoke were suppressed in comparison with that of control rats, and the suppressive effect of nicotine-reduced-cigarette smoke was weaker than that of standard-cigarette smoke. The suppression of theophylline concentrations in plasma induced by exposure to cigarette smoke may be due to nicotine and other constituents of the cigarette smoke, even if the effects are slight. For cimetidine, no difference was found between drug concentration in plasma of rats exposed to nicotine-reduced-cigarette smoke and that of control rats; however, the drug concentration in plasma of rats exposed to standard-cigarette smoke was markedly suppressed. These results suggest that the suppression of cimetidine concentrations in plasma may be due solely to nicotine in cigarette smoke.
研究了大鼠暴露于标准香烟（含尼古丁和焦油）烟雾及低尼古丁香烟烟雾对口服氨茶碱（20毫克/千克）和西咪替丁（50毫克/千克）药代动力学的影响。用“吸烟机”让动物暴露于标准香烟或低尼古丁香烟烟雾中8分钟。在对照大鼠中，血浆中氨茶碱浓度迅速升高，2小时后达到峰值，然后逐渐下降。与对照大鼠相比，暴露于标准香烟和低尼古丁香烟烟雾中的大鼠血浆中氨茶碱浓度受到抑制，且低尼古丁香烟烟雾的抑制作用弱于标准香烟烟雾。即使作用轻微，暴露于香烟烟雾引起的血浆中氨茶碱浓度的抑制可能归因于尼古丁和香烟烟雾中的其他成分。对于西咪替丁，暴露于低尼古丁香烟烟雾的大鼠血浆中药物浓度与对照大鼠之间未发现差异；然而，暴露于标准香烟烟雾的大鼠血浆中药物浓度明显受到抑制。这些结果表明，血浆中西咪替丁浓度的抑制可能仅归因于香烟烟雾中的尼古丁。
